Harnessing Tumor Microenvironment for Nanoparticle‐Mediated Radiotherapy

doi:10.1002/adtp.201800050

IHEP OpenIR > 多学科研究中心

	Harnessing Tumor Microenvironment for Nanoparticle‐Mediated Radiotherapy
	朱双; 谷战军; 赵宇亮; Shuang Zhu; Zhanjun Gu; Yuliang Zhao
	2018
发表期刊	ADVANCED THERAPEUTICS
ISSN	2366-3987
EISSN	2366-3987
卷号	1 期号:5 页码:1800050
文章类型	Article
摘要	Recent years have witnessed the dramatic improvement of nanoparticle‐mediated radiotherapy in preclinical or even clinical cancer research. Among the extensive developments, tumor‐targeted strategies are receiving more and more attention as they become able increase their therapeutic effects as well as reduce the side effects to healthy tissues. The tumor microenvironment (TME) with its critical function in tumor development and distinctive abnormal characteristics, is also widely studied as a target/response for tumor‐specific nano‐radiotherapy. The fast advances of TME‐assisted nano‐radiotherapy have offered numerous novel strategies and approaches for efficiently destroying cancer. This review summarizes the recent advances and development of TME‐enabled nanoparticle‐mediated radiotherapy. Firstly, a brief description of the typical TME characteristics including vasculature, hypoxia, mild acidity, redox reactions, extracellular matrix, and various cellular components is given. Next, the representative examples of TME‐enabled nanoparticle‐mediated radiotherapy are categorized and discussed in two parts: TME components–targeted nano‐radiotherapy and TME characteristics‐responsive nano‐radiotherapy. Lastly, some obstacles and challenges associated with this field are also proposed at the end of this review.
关键词	nanoparticles radiotherapy targeted therapy tumor microenvironments
DOI	10.1002/adtp.201800050
语种	英语
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://ir.ihep.ac.cn/handle/311005/286417
专题	多学科研究中心
通讯作者	谷战军
作者单位	中国科学院高能物理研究所
第一作者单位	中国科学院高能物理研究所
通讯作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	朱双,谷战军,赵宇亮,等. Harnessing Tumor Microenvironment for Nanoparticle‐Mediated Radiotherapy[J]. ADVANCED THERAPEUTICS,2018,1(5):1800050.
APA	朱双,谷战军,赵宇亮,Shuang Zhu,Zhanjun Gu,&Yuliang Zhao.(2018).Harnessing Tumor Microenvironment for Nanoparticle‐Mediated Radiotherapy.ADVANCED THERAPEUTICS,1(5),1800050.
MLA	朱双,et al."Harnessing Tumor Microenvironment for Nanoparticle‐Mediated Radiotherapy".ADVANCED THERAPEUTICS 1.5(2018):1800050.