The progressive supranuclear palsy patients exhibited lower levels of serum cholesterol and protein levels: a retrospective study

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	The progressive supranuclear palsy patients exhibited lower levels of serum cholesterol and protein levels: a retrospective study
	Wang, GH; Huo, Q; Zhan, J; Nie, BB; Shan, BC; Feng, T; Nie BB(聂彬彬); Dan BC(单保慈)
	2016
发表期刊	INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
卷号	9 期号:8 页码:16807
文章类型	期刊论文
摘要	Many studies have showed that the serum cholesterol levels existed significant difference between Parkinson's disease (PD) patients and health controls. However, the serum cholesterol level in progressive supranuclear palsy (PSP) has not been studied. The object of this paper was to examine the levels of serum cholesterol and protein of PSP and their change in the disease progression. 57 possible PSP patients were collected in Beijing Tiantan Hospital from 2002 to 2014. The serum cholesterol and protein level of 57 patients were compared with 89 age-and sex-matched controls. In the 57 PSP patients, 12 patients have been in hospital two or more times. The data of these 12 patients were further analyzed to explore the changes of serum total cholesterol (TC) or total protein (TP) with the course of disease. Our findings showed that the serum TC and TP levels in patients were significantly lower than control. Multivariate logistics regression analysis showed that both TP and TC were independently associated with PSP. The serum protein and cholesterol levels further reduced from first hospitalization to the last time. The results implied that the serum protein and serum cholesterol might played a critical role in the development of PSP.
关键词	Serum cholesterol serum protein parkinson disease progressive supranuclear palsy
关键词[WOS]	PARKINSON-DISEASE ; RISK
WOS类目	Medicine, Research & Experimental
WOS记录号	WOS:000385837700225
引用统计
文献类型	期刊论文
条目标识符	http://ir.ihep.ac.cn/handle/311005/260525
专题	核技术应用研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Wang, GH,Huo, Q,Zhan, J,et al. The progressive supranuclear palsy patients exhibited lower levels of serum cholesterol and protein levels: a retrospective study[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2016,9(8):16807.
APA	Wang, GH.,Huo, Q.,Zhan, J.,Nie, BB.,Shan, BC.,...&单保慈.(2016).The progressive supranuclear palsy patients exhibited lower levels of serum cholesterol and protein levels: a retrospective study.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,9(8),16807.
MLA	Wang, GH,et al."The progressive supranuclear palsy patients exhibited lower levels of serum cholesterol and protein levels: a retrospective study".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 9.8(2016):16807.

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