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Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography
Li J(李娟); Yang WJ(杨文江); Cui RL(崔荣丽); Chang YN(常亚男); Gu WH(古伟宏); Yin WY(尹文艳); Bai X(白雪); Chen K(陈奎); Xia L(夏林); Geng H(耿焕); Xing GM(邢更妹); Li, J; Yang, WJ; Cui, RL; Wang, DL; Chang, YA; Gu, WH; Yin, WY; Bai, X; Chen, K; Xia, L; Geng, H; Xing, GM
2016
发表期刊NANOTECHNOLOGY
卷号27期号:15
通讯作者邢更妹
摘要Fullerenes (C-60) and metallofullerenes (Gd@C-82) have similar chemical structure, but the bio-effects of both fullerene-based materials are. distinct in vivo. Tracking. organic carbon-based materials such as C-60 and Gd@C-82 is difficult in vivo due to the high content of carbon element in the living tissues themselves. In this study, the biodistribution and metabolism of fullerenes (C-60 and Gd@C-82) radiolabeled with Cu-64 were observed by positron emission tomography (PET). Cu-64-C-60 and Cu-64-Gd@C-82 were prepared using 1, 4, 7, 10-tetrakis (carbamoylmethyl)-1, 4, 7, 10-tetra-azacyclodo-decanes grafted on. carbon cages as a. chelator for Cu-64, and were obtained rapidly with high radiochemical yield (>= 90%). The new radio-conjugates were evaluated in vivo in the normal mouse model and. tissue distribution by small animal PET/CT imaging and histology was carried out. The PET imaging, the biodistribution and the excretion of C-60 and Gd@C-82. indicated that C-60 samples have. higher blood retention and. lower renal clearance than the Gd@C-82 samples in vivo and suggested that the differences in. metabolism and distribution in vivo were caused by the structural. differences of the groups on the fullerene cages though there is chemical similarity between C-60 and Gd@C-82.
文章类型期刊论文
关键词Cu-64 radiolabeled fullerenes positron emission tomography imaging biodistribution metabolizer
DOI10.1088/0957-4484/27/15/155101
关键词[WOS]CARBON NANOTUBES ; CANCER-THERAPY ; NANOPARTICLES ; DERIVATIVES ; OXIDATION ; CELLS ; MICROSCOPY ; STABILITY ; VITRO ; XPS
语种英语
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000371343500004
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文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/260300
专题多学科研究中心
核技术应用研究中心
作者单位中国科学院高能物理研究所
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GB/T 7714
Li J,Yang WJ,Cui RL,et al. Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography[J]. NANOTECHNOLOGY,2016,27(15).
APA 李娟.,杨文江.,崔荣丽.,常亚男.,古伟宏.,...&Xing, GM.(2016).Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography.NANOTECHNOLOGY,27(15).
MLA 李娟,et al."Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography".NANOTECHNOLOGY 27.15(2016).
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