Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography

doi:10.1088/0957-4484/27/15/155101

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	Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography
	Li J(李娟); Yang WJ(杨文江); Cui RL(崔荣丽); Chang YN(常亚男); Gu WH(古伟宏); Yin WY(尹文艳); Bai X(白雪); Chen K(陈奎); Xia L(夏林); Geng H(耿焕); Xing GM(邢更妹); Li, J; Yang, WJ; Cui, RL; Wang, DL; Chang, YA; Gu, WH; Yin, WY; Bai, X; Chen, K; Xia, L; Geng, H; Xing, GM
	2016
发表期刊	NANOTECHNOLOGY (IF:3.44[JCR-2016],3.578[5-Year])
ISSN	0957-4484
EISSN	1361-6528
卷号	27 期号:15 页码:155101
通讯作者	邢更妹
文章类型	Article
摘要	Fullerenes (C-60) and metallofullerenes (Gd@C-82) have similar chemical structure, but the bio-effects of both fullerene-based materials are. distinct in vivo. Tracking. organic carbon-based materials such as C-60 and Gd@C-82 is difficult in vivo due to the high content of carbon element in the living tissues themselves. In this study, the biodistribution and metabolism of fullerenes (C-60 and Gd@C-82) radiolabeled with Cu-64 were observed by positron emission tomography (PET). Cu-64-C-60 and Cu-64-Gd@C-82 were prepared using 1, 4, 7, 10-tetrakis (carbamoylmethyl)-1, 4, 7, 10-tetra-azacyclodo-decanes grafted on. carbon cages as a. chelator for Cu-64, and were obtained rapidly with high radiochemical yield (>= 90%). The new radio-conjugates were evaluated in vivo in the normal mouse model and. tissue distribution by small animal PET/CT imaging and histology was carried out. The PET imaging, the biodistribution and the excretion of C-60 and Gd@C-82. indicated that C-60 samples have. higher blood retention and. lower renal clearance than the Gd@C-82 samples in vivo and suggested that the differences in. metabolism and distribution in vivo were caused by the structural. differences of the groups on the fullerene cages though there is chemical similarity between C-60 and Gd@C-82.
关键词	Cu-64 radiolabeled fullerenes positron emission tomography imaging biodistribution metabolizer
DOI	10.1088/0957-4484/27/15/155101
关键词[WOS]	CARBON NANOTUBES ; CANCER-THERAPY ; NANOPARTICLES ; DERIVATIVES ; OXIDATION ; CELLS ; MICROSCOPY ; STABILITY ; VITRO ; XPS
收录类别	SCI ; ADS
语种	英语
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号	WOS:000371343500004
ADS Bibcode	2016Nanot..27o5101L
ADS URL	https://ui.adsabs.harvard.edu/abs/2016Nanot..27o5101L
ADS引文	https://ui.adsabs.harvard.edu/abs/2016Nanot..27o5101L/citations
引用统计	正在获取... 被引频次：0 [ADS]
文献类型	期刊论文
条目标识符	https://ir.ihep.ac.cn/handle/311005/260300
专题	多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Li J,Yang WJ,Cui RL,et al. Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography[J]. NANOTECHNOLOGY,2016,27(15):155101.
APA	李娟.,杨文江.,崔荣丽.,常亚男.,古伟宏.,...&Xing, GM.(2016).Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography.NANOTECHNOLOGY,27(15),155101.
MLA	李娟,et al."Metabolizer in vivo of fullerenes and metallofullerenes by positron emission tomography".NANOTECHNOLOGY 27.15(2016):155101.