Size-Dependent Translocation Pattern, Chemical and Biological Transformation of Nano- and Submicron-Sized Ferric Oxide Particles in the Central Nervous System

doi:10.1166/jnn.2016.11716

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	Size-Dependent Translocation Pattern, Chemical and Biological Transformation of Nano- and Submicron-Sized Ferric Oxide Particles in the Central Nervous System
	Wang, B; Wang, Q; Chen, HQ; Zhou, XY; Wang, HL; Wang, HL; Zhang, J; Feng, WY; Zhang J(张静)
	2016
发表期刊	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷号	16 期号:6 页码:5553-5561
文章类型	期刊论文
摘要	The present study investigated the size-dependent translocation pattern and biological fate of intranasally instilled nano-and submicron-sized Fe2O3 particles (40 nm and 280 nm) in the CNS. The particle translocation in different parts of brain at 4 h, 12 h, 24 h, 3 d, 7 d, and 30 d after intranasal instillation were quantified using ICP-MS method. A biexponential model (correlation coefficient r = 0.98 similar to 0.99) was satisfactory to describe the particokinetic translocation behavior of Fe2O3 nanoparticles in brain. We found a size-dependent translocation pattern and a time-dependent translocation mode for nano-and submicron-sized Fe2O3 nanoparticles in the olfactory bulb, which are most significant in toxic concerns of nanoparticles in the CNS. The TEM images showed particle-like substances of approximately 35-50 nm were located in the axons of olfactory neurons and in the mitochondria and lysosomes of hippocampus cells in the 40 nm-Fe2O3 exposed mice. The synchrotron-based near-edge X-ray absorption spectroscopy (XANES) was used to identify the chemical forms of the nanoparticles in brain. The XANES results indicate that the presence of chemical speciation of the Fe2O3 nanoparticle (similar to 17%) and protein-complex like apotransferrin-Fe2O3 (similar to 16%) in the olfactory bulb, implying that self-coating of Fe2O3 nanoparticles with transferrin occurred in brain. All the findings suggest size-sensitive manners of nano-and submicron-sized Fe2O3 particles in the brain; the smaller one possesses evident detention properties in the CNS versus the larger one.
关键词	Fe2O3 Nanoparticle Size-Dependent Translocation Chemical and Biological Transformation Central Nervous System
DOI	10.1166/jnn.2016.11716
关键词[WOS]	POTENTIAL IMPAIRMENT ; CARBON NANOTUBES ; PROTEIN CORONA ; IN-VIVO ; NANOPARTICLES ; BRAIN ; IRON ; CYTOTOXICITY ; DELIVERY ; DISEASE
语种	英语
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000386123900016
引用统计
文献类型	期刊论文
条目标识符	http://ir.ihep.ac.cn/handle/311005/260256
专题	多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Wang, B,Wang, Q,Chen, HQ,et al. Size-Dependent Translocation Pattern, Chemical and Biological Transformation of Nano- and Submicron-Sized Ferric Oxide Particles in the Central Nervous System[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(6):5553-5561.
APA	Wang, B.,Wang, Q.,Chen, HQ.,Zhou, XY.,Wang, HL.,...&张静.(2016).Size-Dependent Translocation Pattern, Chemical and Biological Transformation of Nano- and Submicron-Sized Ferric Oxide Particles in the Central Nervous System.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(6),5553-5561.
MLA	Wang, B,et al."Size-Dependent Translocation Pattern, Chemical and Biological Transformation of Nano- and Submicron-Sized Ferric Oxide Particles in the Central Nervous System".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.6(2016):5553-5561.

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