The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles
Li W(李炜); Zhao LN(赵丽娜); Zhao YL(赵宇亮); Chen CY(陈春英); Li, W; Zhao, LN; Wei, TT; Zhao, YL; Chen, CY
刊名BIOMATERIALS
2011
卷号32期号:16页码:4030-4041
关键词Fullerene derivative Endocytosis Lysosomal membrane Apoptosis Hsp 70
学科分类Engineering; Materials Science
DOI10.1016/j.biomaterials.2011.02.008
通讯作者[Chen, Chunying] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China ; [Li, Wei ; Zhao, Lina ; Zhao, Yuliang ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosaftey, Beijing 100049, Peoples R China ; [Li, Wei ; Zhao, Lina ; Zhao, Yuliang ; Chen, Chunying] Chinese Acad Sci, Natl Ctr Nanosci & Technol, Beijing 100049, Peoples R China ; [Wei, Taotao] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
文章类型Article
英文摘要Cells undergo apoptosis through two major pathways, the extrinsic pathway (death receptor pathway) and the intrinsic pathway (the mitochondrial pathway). It is well known that nanomaterials of water-soluble fullerene derivatives are potent antioxidants and help to prevent the overproduction of mitochondrial reactive oxygen species (ROS). However, whether their interaction with cells via the death receptor pathway is direct or indirect remains poorly understood. Here, we show that a bis-adduct malonic acid derivative of fullerene, C(60)(C(COOH)(2))(2), inhibits tumor necrosis factor alpha-initiated cellular apoptosis via stabilizing lysosomes. Data presented here demonstrate that nano-sized aggregates of this water-soluble fullerene derivative are endocytosed into cells and enriched in the lysosomes. During the internalization of C(60)(C(COOH)(2))(2), the expression of Hsp 70 is significantly upregulated, promoting cell survival by inhibiting the permeabilization of lysosomal membranes. In addition, the acidic environment inside lysosomes has a marked but temporary effect on the size distribution of fullerenic nanoparticles, and may disperse the aggregated C(60)(C(COOH)(2))(2) nanoparticles into single molecules or smaller aggregates. These single molecules or smaller aggregates may insert into the lysosomal membranes, further stabilizing them and decreasing the release of cathepsins from lysosomes, leading to the inhibition of tumor necrosis factor-induced apoptosis. C(60)(C(COOH)(2))(2) nanoparticles can thus protect cells by stabilizing lysosomal membranes via both upregulated expression of Hsp 70 and by their interactions with lysosomal membranes. (C) 2011 Elsevier Ltd. All rights reserved.
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
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语种英语
WOS记录号WOS:000290196700016
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被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/239956
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
作者单位中国科学院高能物理研究所
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Li W,Zhao LN,Zhao YL,et al. The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles[J]. BIOMATERIALS,2011,32(16):4030-4041.
APA 李炜.,赵丽娜.,赵宇亮.,陈春英.,Li, W.,...&Chen, CY.(2011).The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles.BIOMATERIALS,32(16),4030-4041.
MLA 李炜,et al."The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles".BIOMATERIALS 32.16(2011):4030-4041.
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