The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency

doi:10.1016/S0361-9230(01)00508-1

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	The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency
	Liu NQ(刘年庆); Xu Q(徐清); Hou XL(侯小琳); Liu PS(刘平生); Chai ZF(柴之芳); Liu, NQ; Xu, Q; Hou, XL; Liu, PS; Chai, ZF; Zhu, L; Zhao, ZY; Wang, ZH; Li, YF
	2001
发表期刊	BRAIN RESEARCH BULLETIN
卷号	55 期号:2 页码:309-312
通讯作者	Acad Sinica, Inst High Energy Phys, Lab Nucl Analyt Tech, Beijing 100080, Peoples R China ; Peking Union Med Coll Hosp, Dept Nucl Med, Beijing, Peoples R China
文章类型	Article; Proceedings Paper
摘要	Cretinism is a disease characterized by neurological defects associated with severe iodine deficiency. In a rat model of severe iodine deficiency, we investigated the distribution pattern of trace elements (Iodine [1], selenium [Se], and bromine [Br] in brain tissue samples; potassium [K], calcium [Ca], manganese [Mn], iron [Fe], copper [Cu], zinc [Zn], rubidium [Rb], and lead [Pb] in erythrocytes) after supplementing the rats with I and/or Se. Neutron activation analysis, proton induced x-ray emission and x-ray fluorescence were used. The serum levels of total and free thyroxine (T-4, FT4), and of total, free, and reverse triiodothyronine (T-3, FT3, rT(3), respectively) were assessed by radioimmunoassay. The results were statistically evaluated by one-way analysis of variance and bivariate correlation. The study indicated that the levels of T-4, FT4, and rT(3) increased in the serum of iodine-deficient rats supplemented with I or I + Se. In the same animals, we documented alterations of the content of Br in the brain, and of Zn, Mn, Cu, and Rb in erythrocytes, whereas the brain content of I and Se was unchanged. Thus, I and I + Se supplementation improves thyroid hormone metabolism but affects the content of selected trace elements in erythrocytes and of Br in the brain. The data stimulate further clarification of the role of trace elements in the central nervous system. (C) 2001 Elsevier Science Inc.
关键词	nuclear analytical techniques trace elements metals cretinism
学科领域	Neurosciences & Neurology
研究领域[WOS]	Neurosciences & Neurology ; Neurosciences & Neurology
DOI	10.1016/S0361-9230(01)00508-1
URL	查看原文
语种	英语
研究领域[WOS]	Neurosciences & Neurology ; Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000170112600026
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ihep.ac.cn/handle/311005/236902
专题	院士
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Liu NQ,Xu Q,Hou XL,et al. The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency[J]. BRAIN RESEARCH BULLETIN,2001,55(2):309-312.
APA	刘年庆.,徐清.,侯小琳.,刘平生.,柴之芳.,...&Li, YF.(2001).The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency.BRAIN RESEARCH BULLETIN,55(2),309-312.
MLA	刘年庆,et al."The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency".BRAIN RESEARCH BULLETIN 55.2(2001):309-312.

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