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The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency
Liu NQ(刘年庆); Xu Q(徐清); Hou XL(侯小琳); Liu PS(刘平生); Chai ZF(柴之芳); Liu, NQ; Xu, Q; Hou, XL; Liu, PS; Chai, ZF; Zhu, L; Zhao, ZY; Wang, ZH; Li, YF
刊名BRAIN RESEARCH BULLETIN
2001
卷号55期号:2页码:309-312
关键词nuclear analytical techniques trace elements metals cretinism
学科分类Neurosciences & Neurology
DOI10.1016/S0361-9230(01)00508-1
通讯作者Acad Sinica, Inst High Energy Phys, Lab Nucl Analyt Tech, Beijing 100080, Peoples R China ; Peking Union Med Coll Hosp, Dept Nucl Med, Beijing, Peoples R China
文章类型Article; Proceedings Paper
英文摘要Cretinism is a disease characterized by neurological defects associated with severe iodine deficiency. In a rat model of severe iodine deficiency, we investigated the distribution pattern of trace elements (Iodine [1], selenium [Se], and bromine [Br] in brain tissue samples; potassium [K], calcium [Ca], manganese [Mn], iron [Fe], copper [Cu], zinc [Zn], rubidium [Rb], and lead [Pb] in erythrocytes) after supplementing the rats with I and/or Se. Neutron activation analysis, proton induced x-ray emission and x-ray fluorescence were used. The serum levels of total and free thyroxine (T-4, FT4), and of total, free, and reverse triiodothyronine (T-3, FT3, rT(3), respectively) were assessed by radioimmunoassay. The results were statistically evaluated by one-way analysis of variance and bivariate correlation. The study indicated that the levels of T-4, FT4, and rT(3) increased in the serum of iodine-deficient rats supplemented with I or I + Se. In the same animals, we documented alterations of the content of Br in the brain, and of Zn, Mn, Cu, and Rb in erythrocytes, whereas the brain content of I and Se was unchanged. Thus, I and I + Se supplementation improves thyroid hormone metabolism but affects the content of selected trace elements in erythrocytes and of Br in the brain. The data stimulate further clarification of the role of trace elements in the central nervous system. (C) 2001 Elsevier Science Inc.
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
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语种英语
WOS记录号WOS:000170112600026
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被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/236902
专题院士_期刊论文
作者单位中国科学院高能物理研究所
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Liu NQ,Xu Q,Hou XL,et al. The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency[J]. BRAIN RESEARCH BULLETIN,2001,55(2):309-312.
APA 刘年庆.,徐清.,侯小琳.,刘平生.,柴之芳.,...&Li, YF.(2001).The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency.BRAIN RESEARCH BULLETIN,55(2),309-312.
MLA 刘年庆,et al."The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency".BRAIN RESEARCH BULLETIN 55.2(2001):309-312.
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