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Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube
Zhang S(张爽); Wang XF(王晓峰); Li T(李婷); 刘蕾(多); Wu HC(吴海臣); Li JY(李敬源); Zhang, S; Wang, XF; Li, T; Liu, L; Wu, HC; Luo, MB; Li, JY
2015
发表期刊LANGMUIR
卷号31期号:36页码:10094-10099
文章类型Article
摘要In this work, we use molecular dynamics simulations to study the responses of the configuration of single-strand DNA (ssDNA) within a carbon nanotube (CNT) and the concomitant ion flow to a single modified base, i.e., benzoimidazole (Bzim)-modified 5-hydroxymethyl cytosine (5hmC). Our simulation results show the Bzim-modified 5hmC can considerably increase the ion flow through a single-walled carbon nanotube (SWCNT), despite its larger size, which is consistent with prior experimental results. This phenomenon is attributed to enhanced adsorption of DNA to the interior wall of the CNT driven by the Bzim-modified 5hmC, leading to a reduced steric effect on ion transport through the CNT. As revealed in this work, the distribution of ssDNA can be affected by limited change in the interactions with the CNT surface. Such behavior of ssDNA within small-sized CNTs can be exploited to further improve the sensitivity of nanopore detection.
学科领域Chemistry; Materials Science
DOI10.1021/acs.langmuir.5b01272
收录类别SCI ; EI
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
WOS记录号WOS:000361415900040
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228728
专题多学科研究中心
核技术应用研究中心
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GB/T 7714
Zhang S,Wang XF,Li T,et al. Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube[J]. LANGMUIR,2015,31(36):10094-10099.
APA 张爽.,王晓峰.,李婷.,刘蕾.,吴海臣.,...&Li, JY.(2015).Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube.LANGMUIR,31(36),10094-10099.
MLA 张爽,et al."Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube".LANGMUIR 31.36(2015):10094-10099.
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