Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube

doi:10.1021/acs.langmuir.5b01272

IHEP OpenIR > 多学科研究中心

	Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube
	Zhang S(张爽); Wang XF(王晓峰); Li T(李婷); 刘蕾(多); Wu HC(吴海臣); Li JY(李敬源); Zhang, S; Wang, XF; Li, T; Liu, L; Wu, HC; Luo, MB; Li, JY
	2015
发表期刊	LANGMUIR (IF:3.833[JCR-2016],4.205[5-Year])
ISSN	0743-7463
卷号	31 期号:36 页码:10094-10099
文章类型	Article
摘要	In this work, we use molecular dynamics simulations to study the responses of the configuration of single-strand DNA (ssDNA) within a carbon nanotube (CNT) and the concomitant ion flow to a single modified base, i.e., benzoimidazole (Bzim)-modified 5-hydroxymethyl cytosine (5hmC). Our simulation results show the Bzim-modified 5hmC can considerably increase the ion flow through a single-walled carbon nanotube (SWCNT), despite its larger size, which is consistent with prior experimental results. This phenomenon is attributed to enhanced adsorption of DNA to the interior wall of the CNT driven by the Bzim-modified 5hmC, leading to a reduced steric effect on ion transport through the CNT. As revealed in this work, the distribution of ssDNA can be affected by limited change in the interactions with the CNT surface. Such behavior of ssDNA within small-sized CNTs can be exploited to further improve the sensitivity of nanopore detection.
学科领域	Chemistry; Materials Science
DOI	10.1021/acs.langmuir.5b01272
收录类别	SCI ; EI
语种	英语
WOS研究方向	Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
WOS类目	Chemistry ; Materials Science
WOS记录号	WOS:000361415900040
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://ir.ihep.ac.cn/handle/311005/228728
专题	多学科研究中心核技术应用研究中心
推荐引用方式 GB/T 7714	Zhang S,Wang XF,Li T,et al. Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube[J]. LANGMUIR,2015,31(36):10094-10099.
APA	张爽.,王晓峰.,李婷.,刘蕾.,吴海臣.,...&Li, JY.(2015).Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube.LANGMUIR,31(36),10094-10099.
MLA	张爽,et al."Sensitive Detection of a Modified Base in Single-Stranded DNA by a Single-Walled Carbon Nanotube".LANGMUIR 31.36(2015):10094-10099.