Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference

doi:10.1016/j.pscychresns.2015.04.011

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	Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference
	Tao, HJ; Wong, GHY; Zhang, HR; Zhou, Y; Xue, ZM; Shan, BC; Chen, EYH; Liu, ZN; Dan BC(单保慈)
	2015
发表期刊	PSYCHIATRY RESEARCH-NEUROIMAGING (IF:1.878[JCR-2016],2.745[5-Year])
ISSN	0925-4927
EISSN	1872-7506
卷号	233 期号:1 页码:57-63
文章类型	Article
摘要	Delusions of reference (DOR) are theoretically linked with aberrant salience and associative learning. Previous studies have shown that the caudate nucleus plays a critical role in the cognitive circuits of coding prediction errors and associative learning. The current study aimed at testing the hypothesis that abnormalities in the caudate nucleus may be involved in the neuroanatomical substrate of DOR. Structural magnetic resonance imaging of the brain was performed in 44 first-episode psychosis patients (with diagnoses of schizophrenia or schizophreniform disorder) and 25 healthy controls. Patients were divided into three groups according to symptoms: patients with DOR as prominent positive symptom; patients with prominent positive symptoms other than DOR; and patients with minimal positive symptoms. All groups were age-, gender-, and education-matched, and patient groups were matched for diagnosis, duration of illness, and antipsychotic treatment. Voxel-based morphometric analysis was performed to identify group differences in grey matter density. Relationships were explored between grey matter density and DOR. Patients with DOR were found to have reduced grey matter density in the caudate compared with patients without DOR and healthy controls. Grey matter density values of the left and right caudate head were negatively correlated with DOR severity. Decreased grey matter density in the caudate nucleus may underlie DOR in early psychosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved
关键词	Grey matter morphology Voxel-based morphometry Caudate Delusions
学科领域	Neurosciences & Neurology; Psychiatry
DOI	10.1016/j.pscychresns.2015.04.011
收录类别	SCI
语种	英语
WOS研究方向	Clinical Neurology ; Neuroimaging ; Psychiatry
WOS类目	Neurosciences & Neurology ; Psychiatry
WOS记录号	WOS:000355671600008
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://ir.ihep.ac.cn/handle/311005/228454
专题	核技术应用研究中心
推荐引用方式 GB/T 7714	Tao, HJ,Wong, GHY,Zhang, HR,et al. Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,233(1):57-63.
APA	Tao, HJ.,Wong, GHY.,Zhang, HR.,Zhou, Y.,Xue, ZM.,...&单保慈.(2015).Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference.PSYCHIATRY RESEARCH-NEUROIMAGING,233(1),57-63.
MLA	Tao, HJ,et al."Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference".PSYCHIATRY RESEARCH-NEUROIMAGING 233.1(2015):57-63.