Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor
Liu Y(刘颖); Chen CY(陈春英); Sun BY(孙宝云); Wang LM(王黎明); Gao XF(高兴发); Dong JQ(董金泉); Zhao F(赵峰); Zhao YL(赵宇亮); Liu, Y; Chen, CY; Qian, PX; Lu, XF; Sun, BY; Zhang, X; Wang, LM; Gao, XF; Li, H; Chen, ZY; Tang, JL; Zhang, WJ; Dong, JQ; Bai, R; Lobie, PE; Wu, QF; Liu, SL; Zhang, HF; Zhao, F; Wicha, MS; Zhu, T; Zhao, YL
刊名NATURE COMMUNICATIONS
2015
卷号6页码:5988
学科分类Science & Technology - Other Topics
DOI10.1038/ncomms6988
通讯作者刘颖 ; 陈春英
文章类型Article
英文摘要The contemporary use of nanomedicines for cancer treatment has been largely limited to serving as carriers for existing therapeutic agents. Here, we provide definitive evidence that, the metallofullerenol nanomaterial Gd@C-82(OH)(22), while essentially not toxic to normal mammary epithelial cells, possesses intrinsic inhibitory activity against triple-negative breast cancer cells. Gd@C-82(OH)(22) blocks epithelial-to-mesenchymal transition with resultant efficient elimination of breast cancer stem cells (CSCs) resulting in abrogation of tumour initiation and metastasis. In normoxic conditions, Gd@C-82(OH)(22) mediates these effects by blocking TGF-alpha signalling. Moreover, under hypoxic conditions found in the tumour micro-environment, cellular uptake of Gd@C-82(OH)(22) is facilitated where it functions as a bi-potent inhibitor of HIF-1 alpha and TGF-beta activities, enhancing CSC elimination. These studies indicate that nanomaterials can be engineered to directly target CSCs. Thus, Gd-metallofullerenol is identified as a kind of non-toxic CSC specific inhibitors with significant therapeutic potential.
类目[WOS]Multidisciplinary Sciences
收录类别SCI ; CA
WOS记录号WOS:000348812100006
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/228179
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
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Liu Y,Chen CY,Sun BY,et al. Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor[J]. NATURE COMMUNICATIONS,2015,6:5988.
APA 刘颖.,陈春英.,孙宝云.,王黎明.,高兴发.,...&Zhao, YL.(2015).Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor.NATURE COMMUNICATIONS,6,5988.
MLA 刘颖,et al."Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor".NATURE COMMUNICATIONS 6(2015):5988.
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