Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor

doi:10.1038/ncomms6988

IHEP OpenIR

	Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor
	Liu Y(刘颖); Chen CY(陈春英); Sun BY(孙宝云); Wang LM(王黎明); Gao XF(高兴发); Dong JQ(董金泉); Zhao F(赵峰); Zhao YL(赵宇亮); Liu, Y; Chen, CY; Qian, PX; Lu, XF; Sun, BY; Zhang, X; Wang, LM; Gao, XF; Li, H; Chen, ZY; Tang, JL; Zhang, WJ; Dong, JQ; Bai, R; Lobie, PE; Wu, QF; Liu, SL; Zhang, HF; Zhao, F; Wicha, MS; Zhu, T; Zhao, YL
	2015
发表期刊	NATURE COMMUNICATIONS (IF:12.124[JCR-2016],13.092[5-Year])
ISSN	2041-1723
卷号	6 页码:5988
通讯作者	刘颖 ; 陈春英
文章类型	Article
摘要	The contemporary use of nanomedicines for cancer treatment has been largely limited to serving as carriers for existing therapeutic agents. Here, we provide definitive evidence that, the metallofullerenol nanomaterial Gd@C-82(OH)(22), while essentially not toxic to normal mammary epithelial cells, possesses intrinsic inhibitory activity against triple-negative breast cancer cells. Gd@C-82(OH)(22) blocks epithelial-to-mesenchymal transition with resultant efficient elimination of breast cancer stem cells (CSCs) resulting in abrogation of tumour initiation and metastasis. In normoxic conditions, Gd@C-82(OH)(22) mediates these effects by blocking TGF-alpha signalling. Moreover, under hypoxic conditions found in the tumour micro-environment, cellular uptake of Gd@C-82(OH)(22) is facilitated where it functions as a bi-potent inhibitor of HIF-1 alpha and TGF-beta activities, enhancing CSC elimination. These studies indicate that nanomaterials can be engineered to directly target CSCs. Thus, Gd-metallofullerenol is identified as a kind of non-toxic CSC specific inhibitors with significant therapeutic potential.
学科领域	Science & Technology - Other Topics
DOI	10.1038/ncomms6988
收录类别	SCI ; ADS ; CA
语种	英语
WOS研究方向	Multidisciplinary Sciences
WOS类目	Science & Technology - Other Topics
WOS记录号	WOS:000348812100006
ADS Bibcode	2015NatCo...6.5988L
ADS URL	https://ui.adsabs.harvard.edu/abs/2015NatCo...6.5988L
ADS引文	https://ui.adsabs.harvard.edu/abs/2015NatCo...6.5988L/citations
引用统计	正在获取... 被引频次：32 [ADS]
文献类型	期刊论文
条目标识符	https://ir.ihep.ac.cn/handle/311005/228179
专题	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Liu Y,Chen CY,Sun BY,et al. Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor[J]. NATURE COMMUNICATIONS,2015,6:5988.
APA	刘颖.,陈春英.,孙宝云.,王黎明.,高兴发.,...&Zhao, YL.(2015).Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor.NATURE COMMUNICATIONS,6,5988.
MLA	刘颖,et al."Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor".NATURE COMMUNICATIONS 6(2015):5988.