IHEP OpenIR  > 核技术应用研究中心
Dynamic metabolic changes after permanent cerebral ischemia in rats with/without post-stroke exercise: a positron emission tomography (PET) study
Jiang, XF; Zhang, T; Sy, C; Nie, BB; Hu, XY; Ding, YC;聂彬彬
2014
发表期刊NEUROLOGICAL RESEARCH
卷号36期号:SI5页码:475-482
摘要Recent studies have suggested that rehabilitation therapy can accelerate functional recovery after a stroke. Although often overlooked, the cortical hemisphere contralateral to an infarction plays an important role. This study investigates alterations in metabolism of both the damaged ('ipsilateral') as well as the undamaged ('contralateral') hemisphere using F-18-fluorodeoxyglucose (FDG)-micro-positron emission tomography (PET) in a rat permanent stroke model (with or without post- injury exercise) in order to elucidate the relative importance of either hemisphere to the recovery process following stroke. Methods: Thirty-six adult, male Sprague- Dawley rats were divided into four groups before subsequent surgery: sham controls with or without exercise, and ischemic ('stroke') groups with or without exercise. Fluorodeoxyglucose micro- PET imaging was performed at 7, 14, and 21 days after the designated procedure according to group assignment. The imaging data was analyzed by ANOVA using SPMratIHEP software. Results: Both exercise and ischemia have measurable effects on the motor cortex as well as on the striatum, the effects of which notably include the contralateral hemisphere. To that end, regions of the contralateral motor cortex and striatum have been found to be in a hypermetabolic state following exercise. We further observed that exercise reversed the hypometabolism caused by ischemia back to control levels from day 7 through day 21 on the ipsilateral side. Its effect on the contralateral hemisphere, notably, bolsters an already vigorous response observed after ischemic insult. Thus, the beneficial effect of exercise, as inferred by an increase in metabolic activity, is evident in both hemispheres. Discussion: These findings suggest that the contralateral hemisphere can compensate for the damaged cortex by remodeling neuronal activity. Thus, clinical treatments specifically targeted to the ` intact'hemisphere following stroke may provide a complimentary strategy for promoting recovery of functional deficits and for improving quality of life in stroke patients.
关键词Micro-PET Glucose metabolism Functional recovery Rehabilitation
学科领域Neurosciences & Neurology
DOI10.1179/1743132814Y.0000000350
收录类别SCI
WOS记录号WOS:000337109400014
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225206
专题核技术应用研究中心
推荐引用方式
GB/T 7714
Jiang, XF,Zhang, T,Sy, C,et al. Dynamic metabolic changes after permanent cerebral ischemia in rats with/without post-stroke exercise: a positron emission tomography (PET) study[J]. NEUROLOGICAL RESEARCH,2014,36(SI5):475-482.
APA Jiang, XF,Zhang, T,Sy, C,Nie, BB,Hu, XY,&Ding, YC;聂彬彬.(2014).Dynamic metabolic changes after permanent cerebral ischemia in rats with/without post-stroke exercise: a positron emission tomography (PET) study.NEUROLOGICAL RESEARCH,36(SI5),475-482.
MLA Jiang, XF,et al."Dynamic metabolic changes after permanent cerebral ischemia in rats with/without post-stroke exercise: a positron emission tomography (PET) study".NEUROLOGICAL RESEARCH 36.SI5(2014):475-482.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
11226.pdf(429KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jiang, XF]的文章
[Zhang, T]的文章
[Sy, C]的文章
百度学术
百度学术中相似的文章
[Jiang, XF]的文章
[Zhang, T]的文章
[Sy, C]的文章
必应学术
必应学术中相似的文章
[Jiang, XF]的文章
[Zhang, T]的文章
[Sy, C]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 11226.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。