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Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein | |
Zhang JL(张九龙); Zhang, JL; Gao ZQ(高增强)![]() ![]() | |
2014 | |
发表期刊 | FEBS LETTERS (IF:3.623[JCR-2016],3.424[5-Year]) |
ISSN | 0014-5793 |
EISSN | 1873-3468 |
卷号 | 588期号:10页码:1891-1898 |
摘要 | The bacterial type VI secretion system (T6SS) is used by donor cells to inject toxic effectors into receptor cells. The donor cells produce the corresponding immunity proteins to protect themselves against the effector proteins, thereby preventing their self-intoxication. Recently, the C-terminal domain of VgrG3 was identified as a T6SS effector. Information on the molecular mechanism of VgrG3 and its immunity protein TsaB has been lacking. Here, we determined the crystal structures of native TsaB and the VgrG3C-TsaB complex. VgrG3C adopts a canonical phage-T4-lysozyme-like fold. TsaB interacts with VgrG3C through molecular mimicry, and inserts into the VgrG3C pocket. |
关键词 | The type VI secretion system VgrG3-TsaB complex Glycosyl hydrolase T4-lysozyme-like fold |
学科领域 | Biochemistry & Molecular Biology; Biophysics; Cell Biology |
DOI | 10.1016/j.febslet.2014.04.016 |
收录类别 | SCI ; ADS |
语种 | 英语 |
WOS记录号 | WOS:000336033700006 |
ADS Bibcode | 2014FEBSL.588.1891Z |
ADS URL | https://ui.adsabs.harvard.edu/abs/2014FEBSL.588.1891Z |
ADS引文 | https://ui.adsabs.harvard.edu/abs/2014FEBSL.588.1891Z/citations |
引用统计 | 正在获取...
被引频次:1 [ADS]
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文献类型 | 期刊论文 |
条目标识符 | https://ir.ihep.ac.cn/handle/311005/225013 |
专题 | 中国科学院高能物理研究所 |
推荐引用方式 GB/T 7714 | Zhang JL,Zhang, JL,Gao ZQ,et al. Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein[J]. FEBS LETTERS,2014,588(10):1891-1898. |
APA | 张九龙.,Zhang, JL.,高增强.,Zhang, H.,Gao, ZQ.,...&董宇辉.(2014).Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein.FEBS LETTERS,588(10),1891-1898. |
MLA | 张九龙,et al."Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein".FEBS LETTERS 588.10(2014):1891-1898. |
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