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Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein
Zhang JL(张九龙); Zhang, JL; Gao ZQ(高增强); Zhang, H; Gao, ZQ; Hu, HD; Dong, C; Dong, YH; Dong C(董城); Dong YH(董宇辉)
2014
发表期刊FEBS LETTERS
卷号588期号:10页码:1891-1898
摘要The bacterial type VI secretion system (T6SS) is used by donor cells to inject toxic effectors into receptor cells. The donor cells produce the corresponding immunity proteins to protect themselves against the effector proteins, thereby preventing their self-intoxication. Recently, the C-terminal domain of VgrG3 was identified as a T6SS effector. Information on the molecular mechanism of VgrG3 and its immunity protein TsaB has been lacking. Here, we determined the crystal structures of native TsaB and the VgrG3C-TsaB complex. VgrG3C adopts a canonical phage-T4-lysozyme-like fold. TsaB interacts with VgrG3C through molecular mimicry, and inserts into the VgrG3C pocket.
关键词The type VI secretion system VgrG3-TsaB complex Glycosyl hydrolase T4-lysozyme-like fold
学科领域Biochemistry & Molecular Biology; Biophysics; Cell Biology
DOI10.1016/j.febslet.2014.04.016
收录类别SCI
WOS记录号WOS:000336033700006
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/225013
专题多学科研究中心
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GB/T 7714
Zhang JL,Zhang, JL,Gao ZQ,et al. Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein[J]. FEBS LETTERS,2014,588(10):1891-1898.
APA 张九龙.,Zhang, JL.,高增强.,Zhang, H.,Gao, ZQ.,...&董宇辉.(2014).Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein.FEBS LETTERS,588(10),1891-1898.
MLA 张九龙,et al."Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein".FEBS LETTERS 588.10(2014):1891-1898.
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