The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity
Wang YJ(王雅洁); Wang Z(王喆); Wang, Y; Wang, Z; Joshi, BH; Puri, RK; Stultz, B; Yuan, Q; Bai, Y; Zhou, P; Yuan, Z; Hursh, DA; Bi, X;; Yuan Q(袁卿); Mi XL(秘晓林)
刊名ONCOGENE
2013
卷号32期号:33页码:3857-3866
关键词Apoptosis Caliban p53 tumor suppressor
学科分类Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity
DOI10.1038/onc.2012.395
英文摘要We previously identified Caliban (Clbn) as the Drosophila homolog of human Serologically defined colon cancer antigen 1 gene and demonstrated that it could function as a tumor suppressor in human non-small-cell lung cancer (NSCLC) cells, although its mode of action was unknown. Herein, we identify roles for Clbn in DNA damage response. We generate clbn knockout flies using homologous recombination and demonstrate that they have a heightened sensitivity to irradiation. We show that normal Clbn function facilitates both p53-dependent and -independent DNA damage-induced apoptosis. Clbn coordinates different apoptosis pathways, showing a two-stage upregulation following DNA damage. Clbn has proapoptotic functions, working with both caspase and the proapoptotic gene Hid. Finally, ecotopic expression of clbn(+) in NSCLC cells suppresses tumor formation in athymic nude mice. We conclude that Caliban is a regulator of DNA damage-induced apoptosis, functioning as a tumor suppressor in both p53-dependent and -independent pathways.
收录类别SCI
WOS记录号WOS:000323210200008
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/224246
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
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Wang YJ,Wang Z,Wang, Y,et al. The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity[J]. ONCOGENE,2013,32(33):3857-3866.
APA 王雅洁.,王喆.,Wang, Y.,Wang, Z.,Joshi, BH.,...&秘晓林.(2013).The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity.ONCOGENE,32(33),3857-3866.
MLA 王雅洁,et al."The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity".ONCOGENE 32.33(2013):3857-3866.
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