The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity

doi:10.1038/onc.2012.395

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	The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity
	Wang YJ(王雅洁); Wang Z(王喆); Wang, Y; Wang, Z; Joshi, BH; Puri, RK; Stultz, B; Yuan, Q; Bai, Y; Zhou, P; Yuan, Z; Hursh, DA; Bi, X;; Yuan Q(袁卿); Mi XL(秘晓林)
	2013
发表期刊	ONCOGENE (IF:7.519[JCR-2016],7.272[5-Year])
ISSN	0950-9232
EISSN	1476-5594
卷号	32 期号:33 页码:3857-3866
摘要	We previously identified Caliban (Clbn) as the Drosophila homolog of human Serologically defined colon cancer antigen 1 gene and demonstrated that it could function as a tumor suppressor in human non-small-cell lung cancer (NSCLC) cells, although its mode of action was unknown. Herein, we identify roles for Clbn in DNA damage response. We generate clbn knockout flies using homologous recombination and demonstrate that they have a heightened sensitivity to irradiation. We show that normal Clbn function facilitates both p53-dependent and -independent DNA damage-induced apoptosis. Clbn coordinates different apoptosis pathways, showing a two-stage upregulation following DNA damage. Clbn has proapoptotic functions, working with both caspase and the proapoptotic gene Hid. Finally, ecotopic expression of clbn(+) in NSCLC cells suppresses tumor formation in athymic nude mice. We conclude that Caliban is a regulator of DNA damage-induced apoptosis, functioning as a tumor suppressor in both p53-dependent and -independent pathways.
关键词	Apoptosis Caliban p53 tumor suppressor
学科领域	Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity
DOI	10.1038/onc.2012.395
收录类别	SCI
语种	英语
WOS记录号	WOS:000323210200008
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://ir.ihep.ac.cn/handle/311005/224246
专题	多学科研究中心
推荐引用方式 GB/T 7714	Wang YJ,Wang Z,Wang, Y,et al. The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity[J]. ONCOGENE,2013,32(33):3857-3866.
APA	王雅洁.,王喆.,Wang, Y.,Wang, Z.,Joshi, BH.,...&秘晓林.(2013).The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity.ONCOGENE,32(33),3857-3866.
MLA	王雅洁,et al."The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity".ONCOGENE 32.33(2013):3857-3866.