The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles

doi:10.3109/17435390.2011.590906

IHEP OpenIR

	The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles
	Zhang, LL; Bai, R; Liu, Y; Meng, L; Li, B; Wang, LM; Xu, LG; Le Guyader, L; Chen, CY;李柏
	2012
发表期刊	NANOTOXICOLOGY (IF:6.428[JCR-2016],6.327[5-Year])
卷号	6 期号:5 页码:562-575
摘要	Increasing production and application of metallic nanomaterials are likely to result in the release of these particles into the environment. These released nanoparticles may enter into the lungs and the central nervous system (CNS) directly through inhalation, which therefore poses a potential risk to human health. Herein, we focus on the systemic toxicity and potential influence on the neurotransmitter secretion of intranasally instilled copper nanoparticles (23.5 nm) at three different doses. Copper nanoparticle-exposed mice exhibit pathological lesions at different degrees in certain tissues and especially in lung tissue as revealed by histopathology and transmission electron microscopy (TEM) observations. Inductively-coupled plasma mass spectrometry (ICP-MS) results show that the liver, lung and olfactory bulb are the main tissues in which the copper concentrations increased significantly after exposure to a higher level of Cu nanoparticles (40 mg/kg of body weight). The secretion levels of various neurotransmitters changed as well in some brain regions, especially in the olfactory bulb. Our results indicate that the intranasally instilled copper nanoparticles not only cause the lesions where the copper accumulates, but also affect the neurotransmitter levels in the brain.
关键词	Copper nanoparticles intranasal instillation systemic toxicity neurotransmitter pathological lesion neurotoxicity mouse
学科领域	Science & Technology - Other Topics; Toxicology
DOI	10.3109/17435390.2011.590906
收录类别	SCI
WOS记录号	WOS:000306232200009
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://ir.ihep.ac.cn/handle/311005/224015
专题	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Zhang, LL,Bai, R,Liu, Y,et al. The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles[J]. NANOTOXICOLOGY,2012,6(5):562-575.
APA	Zhang, LL.,Bai, R.,Liu, Y.,Meng, L.,Li, B.,...&Chen, CY；李柏.(2012).The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles.NANOTOXICOLOGY,6(5),562-575.
MLA	Zhang, LL,et al."The dose-dependent toxicological effects and potential perturbation on the neurotransmitter secretion in brain following intranasal instillation of copper nanoparticles".NANOTOXICOLOGY 6.5(2012):562-575.