A method for generating image-derived input function in quantitative F-18-FDG PET study based on the monotonicity of the input and output function curve

doi:10.1097/MNM.0b013e32834f262e

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	A method for generating image-derived input function in quantitative F-18-FDG PET study based on the monotonicity of the input and output function curve
	Zhou S(周山); Zhou, S; Chen, KW; Reiman, EM; La, DM; Shan, BC; Dan BC(单保慈)
	2012
发表期刊	NUCLEAR MEDICINE COMMUNICATIONS (IF:1.472[JCR-2016],1.489[5-Year])
卷号	33 期号:4 页码:362-370
摘要	Objective A method of defining the image-derived input function (IDIF) was introduced and evaluated for the quantification of the regional cerebral metabolic rate of glucose in PET studies. Methods The voxels in the brain vasculature are extracted on the basis of the different monotonicities between the input and the output function curves. Time activity curves (TACs) of such voxels are averaged to obtain the uncorrected TAC of the brain vasculature. The IDIF was obtained from the raw TAC after correcting for the partial volume and spillover effects by an empirical formula in conjunction with a single blood sample and the TAC of the brain tissue. Data from 16 patients were used to test the proposed method. The Patlak approach is used to calculate the net fluoro-2-deoxyglucose clearance with plasma-derived input function and our generated IDIF, respectively. Results The net fluoro-2-deoxyglucose clearances calculated with the IDIF generated by our approach are not only highly correlated (correlation coefficients close to 1) to, but also highly comparable (regression slopes close to 1 and intercepts close to 0) with those calculated with plasma-derived input function. Conclusion The method used in the present work is feasible and accurate. Nucl Med Commun 33:362-370 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
关键词	F-18-fluoro-2-deoxyglucose image-derived input function positron emission tomography regional cerebral metabolic rate of glucose
学科领域	Radiology, Nuclear Medicine & Medical Imaging
DOI	10.1097/MNM.0b013e32834f262e
收录类别	SCI
WOS记录号	WOS:000301767400003
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://ir.ihep.ac.cn/handle/311005/223953
专题	核技术应用研究中心
推荐引用方式 GB/T 7714	Zhou S,Zhou, S,Chen, KW,et al. A method for generating image-derived input function in quantitative F-18-FDG PET study based on the monotonicity of the input and output function curve[J]. NUCLEAR MEDICINE COMMUNICATIONS,2012,33(4):362-370.
APA	周山.,Zhou, S.,Chen, KW.,Reiman, EM.,La, DM.,...&单保慈.(2012).A method for generating image-derived input function in quantitative F-18-FDG PET study based on the monotonicity of the input and output function curve.NUCLEAR MEDICINE COMMUNICATIONS,33(4),362-370.
MLA	周山,et al."A method for generating image-derived input function in quantitative F-18-FDG PET study based on the monotonicity of the input and output function curve".NUCLEAR MEDICINE COMMUNICATIONS 33.4(2012):362-370.