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Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia
Wei, QL; Kang, Z; Diao, FC; Shan, BC; Li, LJ; Zheng, LR; Guo, XF; Liu, CL; Zhang, JB; Zhao, JP;单保慈
2012
发表期刊PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
卷号36期号:1页码:122-127
摘要Background: ZNF804A gene polymorphism rs1344706, the first genetic risk variant to achieve genome wide significance for schizophrenia, has been linked to neural functional connectivity. Dysconnectivity of WM may be the primary pathological mechanism of schizophrenia. Association of this variant with regional WM density has not been investigated in schizophrenic patients. Methods: 69 healthy controls and 80 patients with schizophrenia underwent genotyping of rs1344706 SNPs, and were examined for WM density (T1-weighted MRI). The association of rs1344706 with WM changes in schizophrenia patients and healthy controls was analyzed using a full-factorial 2 x 2 analysis of variance. Results: 1. There was an interaction on WM density in the left prefrontal lobe between the rs1344706 genotype and schizophrenic diagnosis, where the risk T allele carriers presented higher WM density in the schizophrenia patients and lower WM density in healthy controls in comparison with the non-risk allele carriers. 2. The risk allele was associated with an increased WM density of the bilateral hippocampus in both the patients and the healthy group. Limitation: The influence of antipsychotics to the white matter in schizophrenic patients was not fully eliminated. Conclusions: The ZNF804A variant may confer risk for schizophrenia by exerting its effects on the WM in the left prefrontal lobe together with other risk factors for schizophrenia. (C) 2011 Elsevier Inc. All rights reserved.
关键词Magnetic resonance imaging Schizophrenia Single nucleotide polymorphism White matter ZNF804A
学科领域Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
DOI10.1016/j.pnpbp.2011.08.021
收录类别SCI
WOS记录号WOS:000300073000019
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被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/223856
专题核技术应用研究中心
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GB/T 7714
Wei, QL,Kang, Z,Diao, FC,et al. Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2012,36(1):122-127.
APA Wei, QL.,Kang, Z.,Diao, FC.,Shan, BC.,Li, LJ.,...&Zhao, JP;单保慈.(2012).Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,36(1),122-127.
MLA Wei, QL,et al."Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 36.1(2012):122-127.
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