Solid-state and biological nanopore for real-time sensing of single chemical and sequencing of DNA
Haque, F; Li, JH; Wu HC(吴海臣); Wu, HC; Liang, XJ; Guo, PX
刊名NANO TODAY
2013
卷号8期号:1页码:56-74
关键词Bacteriophage phi29 alpha-Hemolysin MspA Solid state pore Synthetic nanopores DNA packaging Nanomotor Connector Liposomes Ion channel Single channel conductance Membrane channel Viral assembly Stoichiometry quantification Nanostructure Bionanotechnology Nanobiotechnology Nanomedicine
学科分类Chemistry; Science & Technology - Other Topics; Materials Science
DOI10.1016/j.nantod.2012.12.008
英文摘要Sensitivity and specificity are two most important factors to take into account for molecule sensing, chemical detection and disease diagnosis. A perfect sensitivity is to reach the level where a single molecule can be detected. An ideal specificity is to reach the level where the substance can be detected in the presence of many contaminants. The rapidly progressing nanopore technology is approaching this threshold. A wide assortment of biomotors and cellular pores in living organisms perform diverse biological functions. The elegant design of these transportation machineries has inspired the development of single molecule detection based on modulations of the individual current blockage events. The dynamic growth of nanotechnology and nanobiotechnology has stimulated rapid advances in the study of nanopore based instrumentation over the last decade, and inspired great interest in sensing of single molecules including ions, nucleotides, enantiomers, drugs, and polymers such as PEG, RNA, DNA, and polypeptides. This sensing technology has been extended to medical diagnostics and third generation high throughput DNA sequencing. This review covers current nanopore detection platforms including both biological pores and solid state counterparts. Several biological nanopores have been studied over the years, but this review will focus on the three best characterized systems including et-hemolysin and MspA, both containing a smaller channel for the detection of single stranded DNA, as well as bacteriophage phi29 DNA packaging motor connector that contains a larger channel for the passing of double stranded DNA. The advantage and disadvantage of each system are compared; their current and potential applications in nanonnedicine, biotechnology, and nanotechnology are discussed. (C) 2013 Elsevier Ltd. All rights reserved.
收录类别SCI
WOS记录号WOS:000318050600008
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被引频次:111[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ihep.ac.cn/handle/311005/223807
专题中国科学院高能物理研究所_多学科研究中心_期刊论文
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Haque, F,Li, JH,Wu HC,et al. Solid-state and biological nanopore for real-time sensing of single chemical and sequencing of DNA[J]. NANO TODAY,2013,8(1):56-74.
APA Haque, F,Li, JH,吴海臣,Wu, HC,Liang, XJ,&Guo, PX.(2013).Solid-state and biological nanopore for real-time sensing of single chemical and sequencing of DNA.NANO TODAY,8(1),56-74.
MLA Haque, F,et al."Solid-state and biological nanopore for real-time sensing of single chemical and sequencing of DNA".NANO TODAY 8.1(2013):56-74.
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