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| Stimuli-Responsive Manganese Single-Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions | |
| BSRF用户 | |
| 2021 | |
| Source Publication | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| ISSN | 1433-7851 |
| EISSN | 1521-3773 |
| Volume | 60Issue:17Pages:9480--9488 |
| ItemNo | BSRF00896 |
| Subtype | Article |
| Abstract | The single-atom enzyme (SAE) is a novel type of nanozyme that exhibits extraordinary catalytic activity. Here, we constructed a PEGylated manganese-based SAE (Mn/PSAE) by coordination of single-atom manganese to nitrogen atoms in hollow zeolitic imidazolate frameworks. Mn/PSAE catalyzes the conversion of cellular H2O2 to (OH)-O-. through a Fenton-like reaction; it also promotes the decomposition of H2O2 to O-2 and continuously catalyzes the conversion of O-2 to cytotoxic O-.(2)- via oxidase-like activity. The catalytic activity of Mn/PSAE is more pronounced in the weak acidic tumor environment; therefore, these cascade reactions enable the sufficient generation of reactive oxygen species (ROS) and effectively kill tumor cells. The prominent photothermal conversion property of the amorphous carbon can be utilized for photothermal therapy. Hence, Mn/PSAE exhibits significant therapeutic efficacy through tumor microenvironment stimulated generation of multiple ROS and photothermal activity. |
| DOI | 10.1002/anie.202017152 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| WOS ID | WOS:000627485000001 |
| beamline | 1W1B |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/293664 |
| Collection | 北京同步辐射装置 |
| Recommended Citation GB/T 7714 | BSRF用户. Stimuli-Responsive Manganese Single-Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2021,60(17):9480--9488. |
| APA | BSRF用户.(2021).Stimuli-Responsive Manganese Single-Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,60(17),9480--9488. |
| MLA | BSRF用户."Stimuli-Responsive Manganese Single-Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60.17(2021):9480--9488. |
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