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Bi2S3-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo
Song L(宋丽); Dong XH(董兴华); Zhu S(朱双); Yin WY(尹文艳); Zhang X(张潇); Gu ZJ(谷战军); Song, L.; Dong, X.; Zhu, S.; Zhang, C.; Yin, W.; Zhang, X.; Liu, X.; Gu, Z.
2018
Source PublicationADVANCED HEALTHCARE MATERIALS
ISSN2192-2640
EISSN2192-2659
Volume7Issue:22Pages:1800830
SubtypeArticle
AbstractAlthough various types of photothermal agents are developed for photothermal cancer therapy, relatively few photothermal agents exhibit high tumor inhibition rate under relatively mild conditions. Herein, a multifunctional Bi2S3-Tween 20 nanoplatform loaded with PI3K inhibitor LY294002 is designed as a novel photothermal agent for inhibitor and photothermal synergistic therapy of tumors under mild photothermal therapy conditions. The LY294002 of PI3K inhibitor, after being loaded by Bi2S3-Tween 20 nanodots, exhibits greatly increased drug utilization and reduced side effects on normal tissues. In vivo, Bi2S3-Tween 20@LY294002 upon near-infrared 808 nm laser irradiation shows potent antitumor activity under relatively mild conditions (power density: 0.6 W cm(-2)). Moreover, the mechanism studies also demonstrate that Bi2S3-Tween 20@LY294002 potently kills LoVo cancer cells under low-power near-infrared light irradiation, by downregulating the expression of heat shock protein 70 (HSP70) so as to increase the sensitivity of tumor cell hyperthermia and activating BAX/BAK-regulated mitochondrial apoptosis pathway. The results demonstrate that the newly synthesized multifunctional nanoplatform paves a new avenue for accurate therapy of photothermal-resistant cancer.
KeywordBi2S3-Tween 20 nanodots LY294002 mild photothermal therapy photothermal-resistant PI3K inhibitors
DOI10.1002/adhm.201800830
WOS KeywordDRUG-DELIVERY ; CANCER ; NANOPARTICLES ; NANOSHEETS ; HYPERTHERMIA ; NANOSPHERES ; NANORODS ; 3-KINASE ; CARRIER ; AGENT
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Science & Technology - Other Topics ; Materials Science
WOS SubjectEngineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS IDWOS:000450785100009
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/287006
Collection多学科研究中心
实验物理中心
Corresponding AuthorGu ZJ(谷战军)
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Corresponding Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Song L,Dong XH,Zhu S,et al. Bi2S3-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(22):1800830.
APA 宋丽.,董兴华.,朱双.,尹文艳.,张潇.,...&Gu, Z..(2018).Bi2S3-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo.ADVANCED HEALTHCARE MATERIALS,7(22),1800830.
MLA 宋丽,et al."Bi2S3-Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo".ADVANCED HEALTHCARE MATERIALS 7.22(2018):1800830.
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