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pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells
Zhou MX(周梦雪); Xie J(谢进); Qi RX(齐荣翔); Lu HR(卢会茹); Chen J(陈俊); Hu Y(胡毅); Zhou, M.; Zhang, X.; Xie, J.; Qi, R.; Lu, H.; Leporatti, S.; Chen, J.; Hu, Y.
2018
Source PublicationNANOMATERIALS
ISSN2079-4991
Volume8Issue:11Pages:952
SubtypeArticle
AbstractMultidrug resistance (MDR) remains an unmet challenge in chemotherapy. Stimuli-responsive nanocarriers emerge as a promising tool to overcome MDR. Herein, pH-sensitive poly(beta-amino ester)s polymers (PHP)-based micellar nanoparticles were synthesized for enhanced doxorubicin (DOX) delivery in drug resistant breast cancer MCF-7/ADR cells. DOX-loaded PHP micelles showed rapid cell-internalization and lysosomal escape in MCF-7/ADR cells. The cytotoxicity assays showed relatively higher cell inhibition of DOX-loaded PHP micelles than that of free DOX against MCF-7/ADR cells. Further mechanistic studies showed that PHP micelles were able to inhibit P-glycoprotein (P-gp) activity by lowering mitochondrial membrane potentials and ATP levels. These results suggested that the enhanced antitumor effect might be attributed to PHP-mediated lysosomal escape and drug efflux inhibition. Therefore, PHP would be a promising pH-responsive nanocarrier for enhanced intracellular drug delivery and overcoming MDR in cancer cells.
Keywordnanoparticles pH responsive poly(beta-amino ester)s doxorubicin multidrug resistance
DOI10.3390/nano8110952
WOS KeywordVITAMIN-E TPGS ; MULTIDRUG-RESISTANCE ; DOXORUBICIN DELIVERY ; ANTICANCER DRUG ; IN-VITRO ; NANOPARTICLES ; COPOLYMER ; MICELLES ; REVERSAL ; METASTASIS
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000451316100087
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/286982
Collection多学科研究中心
实验物理中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Zhou MX,Xie J,Qi RX,et al. pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells[J]. NANOMATERIALS,2018,8(11):952.
APA 周梦雪.,谢进.,齐荣翔.,卢会茹.,陈俊.,...&Hu, Y..(2018).pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells.NANOMATERIALS,8(11),952.
MLA 周梦雪,et al."pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells".NANOMATERIALS 8.11(2018):952.
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