| pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells | |
Zhou MX(周梦雪); Xie J(谢进); Qi RX(齐荣翔); Lu HR(卢会茹); Chen J(陈俊) ; Hu Y(胡毅); Zhou, M.; Zhang, X.; Xie, J.; Qi, R.; Lu, H.; Leporatti, S.; Chen, J.; Hu, Y.
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| 2018 | |
| Source Publication | NANOMATERIALS
 |
| ISSN | 2079-4991 |
| Volume | 8Issue:11Pages:952 |
| Subtype | Article |
| Abstract | Multidrug resistance (MDR) remains an unmet challenge in chemotherapy. Stimuli-responsive nanocarriers emerge as a promising tool to overcome MDR. Herein, pH-sensitive poly(beta-amino ester)s polymers (PHP)-based micellar nanoparticles were synthesized for enhanced doxorubicin (DOX) delivery in drug resistant breast cancer MCF-7/ADR cells. DOX-loaded PHP micelles showed rapid cell-internalization and lysosomal escape in MCF-7/ADR cells. The cytotoxicity assays showed relatively higher cell inhibition of DOX-loaded PHP micelles than that of free DOX against MCF-7/ADR cells. Further mechanistic studies showed that PHP micelles were able to inhibit P-glycoprotein (P-gp) activity by lowering mitochondrial membrane potentials and ATP levels. These results suggested that the enhanced antitumor effect might be attributed to PHP-mediated lysosomal escape and drug efflux inhibition. Therefore, PHP would be a promising pH-responsive nanocarrier for enhanced intracellular drug delivery and overcoming MDR in cancer cells. |
| Keyword | nanoparticles pH responsive poly(beta-amino ester)s doxorubicin multidrug resistance |
| DOI | 10.3390/nano8110952 |
| WOS Keyword | VITAMIN-E TPGS ; MULTIDRUG-RESISTANCE ; DOXORUBICIN DELIVERY ; ANTICANCER DRUG ; IN-VITRO ; NANOPARTICLES ; COPOLYMER ; MICELLES ; REVERSAL ; METASTASIS |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| WOS ID | WOS:000451316100087 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/286982 |
| Collection | 多学科研究中心 实验物理中心 |
| Affiliation | 中国科学院高能物理研究所 |
| First Author Affilication | Institute of High Energy |
| Recommended Citation GB/T 7714 | Zhou MX,Xie J,Qi RX,et al. pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells[J]. NANOMATERIALS,2018,8(11):952. |
| APA | 周梦雪.,谢进.,齐荣翔.,卢会茹.,陈俊.,...&Hu, Y..(2018).pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells.NANOMATERIALS,8(11),952. |
| MLA | 周梦雪,et al."pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells".NANOMATERIALS 8.11(2018):952. |
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