| Advanced Nuclear and Related Techniques for Metallomics and Nanometallomics | |
Li YF(李玉锋) ; Zhao JT(赵甲亭); Gao YX(高愈希); Chai ZF(柴之芳); Li, Yu-Feng; Zhao, Jiating; Gao, Yuxi; Chen, Chunying; Chai, Zhifang
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| 2018 | |
| Source Publication | METALLOMICS: THE SCIENCE OF BIOMETALS
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| ISSN | 0065-2598 |
| EISSN | 2214-8019 |
| Pages | 213-243 |
| Subtype | Article; Book Chapter |
| Abstract | Metallomics, focusing on the global and systematic understanding of the metal uptake, trafficking, role, and excretion in biological systems, has attracted more and more attention. Metal-related nanomaterials, including metallic and metal-containing nanomaterials, have unique properties compared to their macroscale counterparts and therefore require special attention. The absorption, distribution, metabolism, excretion (ADME) behavior of metal-related nanomaterials in the biological systems is influenced by their physicochemical properties, the exposure route, and the microenvironment of the deposition site. Nanomaterials not only may interact directly or indirectly with genes, proteins, and other molecules to bring genotoxicity, immunotoxicity, DNA damage, and cytotoxicity but may also stimulate the immune responses, circumvent tumor resistance, and inhibit tumor metastasis. Because of their advantages of absolute quantification, high sensitivity, excellent accuracy and precision, low matrix effects, and nondestructiveness, nuclear and related analytical techniques have been playing important roles in the study of metallomics and nanometallomics. In this chapter, we present a comprehensive overview of nuclear and related analytical techniques applied to the quantification of metallome and nanometallome, the biodistribution, bioaccumulation, and transformation of metallome and nanometallome in vivo, and the structural analysis. Besides, metallomics and nanometallomics need to cooperate with other -omics, like genomics, proteomics, and metabolomics, to obtain the knowledge of underlying mechanisms and therefore to improve the application performance and to reduce the potential risk of metallome and nanometallome. |
| Keyword | Metallomics Nanometallomics Nuclear analytical techniques Metals Metal-related nanomaterials |
| DOI | 10.1007/978-3-319-90143-5_9 |
| WOS Keyword | X-RAY-FLUORESCENCE ; PLASMA-MASS SPECTROMETRY ; ABLATION-ICP-MS ; MOLECULAR ACTIVATION-ANALYSIS ; INHALED ULTRAFINE PARTICLES ; INTEGRATED BIOMETAL SCIENCE ; PROTEIN SECONDARY STRUCTURE ; SEMICONDUCTOR QUANTUM DOTS ; RESOLVED TRACE ANALYSIS ; MICRO-XRF SPECTROMETER |
| Indexed By | SCI ; MEDLINE |
| Language | 英语 |
| WOS Research Area | Life Sciences & Biomedicine - Other Topics ; Research & Experimental Medicine |
| WOS Subject | Biology ; Medicine, Research & Experimental |
| WOS ID | WOS:000448876600010 |
| MedlineID | MEDLINE:29884967 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/286909 |
| Collection | 多学科研究中心 |
| Corresponding Author | Chai ZF(柴之芳) |
| Affiliation | 中国科学院高能物理研究所 |
| First Author Affilication | Institute of High Energy |
| Corresponding Author Affilication | Institute of High Energy |
| Recommended Citation GB/T 7714 | Li YF,Zhao JT,Gao YX,et al. Advanced Nuclear and Related Techniques for Metallomics and Nanometallomics[J]. METALLOMICS: THE SCIENCE OF BIOMETALS,2018:213-243. |
| APA | 李玉锋.,赵甲亭.,高愈希.,柴之芳.,Li, Yu-Feng.,...&Chai, Zhifang.(2018).Advanced Nuclear and Related Techniques for Metallomics and Nanometallomics.METALLOMICS: THE SCIENCE OF BIOMETALS,213-243. |
| MLA | 李玉锋,et al."Advanced Nuclear and Related Techniques for Metallomics and Nanometallomics".METALLOMICS: THE SCIENCE OF BIOMETALS (2018):213-243. |
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