|Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles|
|Gu WH(古伟宏); Chen K(陈奎); Zhang XY(张小艺); Li J(李娟); Qin YX(秦艳霞); Bai X(白雪); Chang YN(常亚男); Xia SB(夏士博); Zhang JX(张佳欣); Ma SH(马思汉); Qin YX(秦艳霞); Wu ZH(吴忠华); Xing GM(邢更妹); Gu, Weihong; Chen, Kui; Zhao, Xiaoyi; Geng, Huan; Li, Juan; Qin, Yanxia; Bai, Xue; Chang, Ya-Nan; Xia, Shibo; Zhang, Jiaxin; Ma, Sihan; Wu, Zhonghua; Xing, Gengyan; Xing, Gengmei
|Abstract||Osteoporosis, a common and serious bone disorder affecting aged people and postmenopausal women, is characterized by osteoclast overactivity. One therapeutic strategy is suppressing the bone resorption function of hyperactive osteoclasts, but there is no effective drug in clinical practice so far. Herein, it is demonstrated that fullerenols suppress the bone resorption of osteoclasts by inhibiting ruffled borders (RBs) formation. The RBs formation, which is supported by well-aligned actin bundles (B-actins), is a critical event for osteoclast bone resorption. To facilitate this function, osteoclast RBs dynamics is regulated by variable microenvironments to bundle F-actins, protrude cell membrane, and so on. B-actin perturbation by fullerenols is determined here, offering an opportunity to regulate osteoclast function by destroying RBs. In vivo, the therapeutic effect of fullerenols on overactive osteoclasts is confirmed in a mouse model of lipopolysaccharide-induced bone erosion. Collectively, the findings suggest that fullerenols adhere to F-actin surfaces and inhibit RBs formation in osteoclasts, mainly through hampering Ca2+ from bundling F-actins, and this is likely due to the stereo-hindrance effect caused by adherent fullerenols.|
synchrotron radiation small angle X-ray scattering (SAXS)
; CELLULAR UPTAKE
|WOS Research Area||Chemistry
; Science & Technology - Other Topics
; Materials Science
|WOS Subject||Chemistry, Multidisciplinary
; Chemistry, Physical
; Nanoscience & Nanotechnology
; Materials Science, Multidisciplinary
; Physics, Applied
; Physics, Condensed Matter
|EI Accession Number||20184305976260
|Corresponding Author||Xing GM(邢更妹)|
|First Author Affilication||Institute of High Energy
|Corresponding Author Affilication||Institute of High Energy
Gu WH,Chen K,Zhang XY,et al. Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles[J]. SMALL,2018,14(48):1802549.
古伟宏.,陈奎.,张小艺.,李娟.,秦艳霞.,...&Xing, Gengmei.(2018).Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles.SMALL,14(48),1802549.
古伟宏,et al."Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles".SMALL 14.48(2018):1802549.
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