| Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin | |
Wen KK(温凯凯); Zhou MX(周梦雪); Lu HR(卢会茹); Bi Y(毕颖); Ruan LF(阮利佛); Chen J(陈俊) ; Hu Y(胡毅); Wen, Kaikai; Zhou, Mengxue; Lu, Huiru; Bi, Ying; Ruan, Lifo; Chen, Jun; Hu, Yi; Wen, Kaikai, Zhou, Mengxue, Lu, Huiru, Bi, Ying, Ruan, Lifo, Chen, Jun; Hu, Yi
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| 2018 | |
| Source Publication | ACS BIOMATERIALS SCIENCE & ENGINEERING
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| ISSN | 2373-9878 |
| Volume | 4Issue:12Pages:4244-4254 |
| Subtype | Article |
| Abstract | Herein, we designed near-infrared (NIR)/pH dual-sensitive nanocarriers and evaluated its application to intracellular drug delivery. The nanocarriers were prepared based on amphiphilic poly(beta-amino ester) (PBAE) containing o-nitrobenzyl moieties in the backbones and upconversion nano particles (UCNPs). UCNPs can convert NIR to UV that subsequently removes PEG segments from PBAE copolymers, which could enhance the protonation of PBAE in endo/lysosomes and facilitate the escape of the nanoparticles from lysosomes. In addition, we found the colocalization of the nanoparticles with mitochondria inside the cells, presumably resulting from high hydrophobicity and positive charges of the nanoparticles. The results showed that the nanocarriers with the aid of NIR could enhance the intracellular delivery of DOX, as compared with free DOX and NIR-free control. Furthermore PBAE@UCNPs-DOX with NIR potently inhibited tumor growth in mice. Therefore, the intelligent micellar nanoparticles might provide a simple yet effective nanoplatform to achieve mitochondrion-targeting drug delivery. |
| Keyword | near-infrared poly(beta-amino ester) upconversion nanoparticles intracellular drug delivery mitochondrion |
| DOI | 10.1021/acsbiomaterials.8b01051 |
| WOS Keyword | ANTICANCER DRUG-DELIVERY ; ENERGY-TRANSFER ; NANOPARTICLES ; MITOCHONDRIA |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS Research Area | Materials Science |
| WOS Subject | Materials Science, Biomaterials |
| WOS ID | WOS:000453109000033 |
| EI Accession Number | 20184906204960 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/286872 |
| Collection | 多学科研究中心 |
| Affiliation | 中国科学院高能物理研究所 |
| First Author Affilication | Institute of High Energy |
| Recommended Citation GB/T 7714 | Wen KK,Zhou MX,Lu HR,et al. Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2018,4(12):4244-4254. |
| APA | 温凯凯.,周梦雪.,卢会茹.,毕颖.,阮利佛.,...&Hu, Yi.(2018).Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin.ACS BIOMATERIALS SCIENCE & ENGINEERING,4(12),4244-4254. |
| MLA | 温凯凯,et al."Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin".ACS BIOMATERIALS SCIENCE & ENGINEERING 4.12(2018):4244-4254. |
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