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Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin
Wen KK(温凯凯); Zhou MX(周梦雪); Lu HR(卢会茹); Bi Y(毕颖); Ruan LF(阮利佛); Chen J(陈俊); Hu Y(胡毅); Wen, Kaikai; Zhou, Mengxue; Lu, Huiru; Bi, Ying; Ruan, Lifo; Chen, Jun; Hu, Yi; Wen, Kaikai, Zhou, Mengxue, Lu, Huiru, Bi, Ying, Ruan, Lifo, Chen, Jun; Hu, Yi
2018
Source PublicationACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN2373-9878
Volume4Issue:12Pages:4244-4254
SubtypeArticle
AbstractHerein, we designed near-infrared (NIR)/pH dual-sensitive nanocarriers and evaluated its application to intracellular drug delivery. The nanocarriers were prepared based on amphiphilic poly(beta-amino ester) (PBAE) containing o-nitrobenzyl moieties in the backbones and upconversion nano particles (UCNPs). UCNPs can convert NIR to UV that subsequently removes PEG segments from PBAE copolymers, which could enhance the protonation of PBAE in endo/lysosomes and facilitate the escape of the nanoparticles from lysosomes. In addition, we found the colocalization of the nanoparticles with mitochondria inside the cells, presumably resulting from high hydrophobicity and positive charges of the nanoparticles. The results showed that the nanocarriers with the aid of NIR could enhance the intracellular delivery of DOX, as compared with free DOX and NIR-free control. Furthermore PBAE@UCNPs-DOX with NIR potently inhibited tumor growth in mice. Therefore, the intelligent micellar nanoparticles might provide a simple yet effective nanoplatform to achieve mitochondrion-targeting drug delivery.
Keywordnear-infrared poly(beta-amino ester) upconversion nanoparticles intracellular drug delivery mitochondrion
DOI10.1021/acsbiomaterials.8b01051
WOS KeywordANTICANCER DRUG-DELIVERY ; ENERGY-TRANSFER ; NANOPARTICLES ; MITOCHONDRIA
Indexed BySCI ; EI
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000453109000033
EI Accession Number20184906204960
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/286872
Collection多学科研究中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Wen KK,Zhou MX,Lu HR,et al. Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2018,4(12):4244-4254.
APA 温凯凯.,周梦雪.,卢会茹.,毕颖.,阮利佛.,...&Hu, Yi.(2018).Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin.ACS BIOMATERIALS SCIENCE & ENGINEERING,4(12),4244-4254.
MLA 温凯凯,et al."Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin".ACS BIOMATERIALS SCIENCE & ENGINEERING 4.12(2018):4244-4254.
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