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Functionalized MoS2 Nanovehicle with Near-Infrared Laser-Mediated Nitric Oxide Release and Photothermal Activities for Advanced Bacteria-Infected Wound Therapy
Gao Q(高琴); Zhang X(张潇); Yin WY(尹文艳); Ma DQ(马冬青); Xie CJ(谢昌健); Zheng LR(郑黎荣); Dong XH(董兴华); Mei LQ(梅林强); Yu J(余杰); Gu ZJ(谷战军); Zhao YL(赵宇亮); Gao, Qin, Zhang, Xiao, Yin, Wenyan, Ma, Dongqing, Xie, Changjian, Zheng, Lirong, Dong, Xinghua, Mei, Linqiang, Yu, Jie, Wang, Chaozhan, Gu, Zhanjun; Zhao, Yuliang
2018
Source PublicationSMALL
ISSN1613-6810
EISSN1613-6829
Volume14Issue:45Pages:1802290
SubtypeArticle
AbstractThe rising dangers of bacterial infections have created an urgent need for the development of a new generation of antibacterial nanoagents and therapeutics. A new near-infrared 808 nm laser-mediated nitric oxide (NO)-releasing nanovehicle (MoS2-BNN6) is reported through the simple assembly of alpha-cyclodextrin-modified MoS2 nanosheets with a heat-sensitive NO donor N,N '-di-sec-butyl-N,N '-dinitroso-1,4-phenylenediamine (BNN6) for the rapid and effective treatment of three typical Gram-negative and Gram-positive bacteria (ampicillin-resistant Escherichia coli, heat-resistant Escherichia faecalis, and pathogen Staphylococcus aureus). This MoS2-BNN6 nanovehicle has good biocompatibility and can be captured by bacteria to increase opportunities of NO diffusion to the bacterial surface. Once stimulated by 808 nm laser irradiation, the MoS2-BNN6 nanovehicle not only exhibits photothermal therapy (PTT) efficacy but also can precisely control NO release, generating oxidative/nitrosative stress. The temperature-enhanced catalytic function of MoS2 induced by 808 nm laser irradiation simultaneously accelerates the oxidation of glutathione. This acceleration disrupts the balance of antioxidants, ultimately resulting in significant DNA damage to the bacteria. Within 10 min, the MoS2-BNN6 with enhanced PTT/NO synergetic antibacterial function achieves >97.2% inactivation of bacteria. The safe synergetic therapy strategy can also effectively repair wounds through the formation of collagen fibers and elimination of inflammation during tissue reconstruction.
Keywordhyperthermia light-mediated synergetic therapy MoS2 wound disinfection and healing
DOI10.1002/smll.201802290
WOS KeywordCHEMICALLY EXFOLIATED MOS2 ; ANTIBACTERIAL ACTIVITY ; SILVER NANOPARTICLES ; ESCHERICHIA-COLI ; CANCER-THERAPY ; QUANTUM DOTS ; COMET ASSAY ; GRAPHENE ; RESISTANCE ; NANOSHEETS
Indexed BySCI ; EI
Language英语
WOS Research AreaEnvironmental Sciences & Ecology ; Meteorology & Atmospheric Sciences
WOS SubjectEnvironmental Sciences ; Meteorology & Atmospheric Sciences
WOS IDWOS:000449542800019
EI Accession Number20184205952949
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/286850
Collection多学科研究中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Gao Q,Zhang X,Yin WY,et al. Functionalized MoS2 Nanovehicle with Near-Infrared Laser-Mediated Nitric Oxide Release and Photothermal Activities for Advanced Bacteria-Infected Wound Therapy[J]. SMALL,2018,14(45):1802290.
APA 高琴.,张潇.,尹文艳.,马冬青.,谢昌健.,...&Zhao, Yuliang.(2018).Functionalized MoS2 Nanovehicle with Near-Infrared Laser-Mediated Nitric Oxide Release and Photothermal Activities for Advanced Bacteria-Infected Wound Therapy.SMALL,14(45),1802290.
MLA 高琴,et al."Functionalized MoS2 Nanovehicle with Near-Infrared Laser-Mediated Nitric Oxide Release and Photothermal Activities for Advanced Bacteria-Infected Wound Therapy".SMALL 14.45(2018):1802290.
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