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Interaction between Surface Charge-Modified Gold Nanoparticles and Phospholipid Membranes
Xing XQ(邢雪青); Xing, XQ; Zhao XY(赵晓艺); Wang JY(王佳怡); Yao L(姚磊); Wu ZH(吴忠华); Ma, WS; Zhao, XY; Wang, JY; Yao, L; Jiang, XY; Wu, ZH
2018
Source PublicationLANGMUIR
ISSN0743-7463
Volume34Issue:42Pages:12583-12589
SubtypeArticle
AbstractThis report clarifies the interaction of surface charge-modified gold nanoparticles (AuNPs) with phospholipid membranes, which is helpful to understand the antibacterial mechanism of positive charge-modified AuNPs to Gram-negative bacteria. Although the simulated bacterial cell membranes as a whole are negatively charged, the local electrostatic repulsive interaction between the positive charge-coated AuNPs and the small-sized flexible cationic head group of dioleyl phosphatidylethanolamine molecules induces the phase transformation of the simulated bacterial cell membranes from a lamellar to an inverted hexagonal phase. Transmembrane pores with a diameter of about 3.0 nm in the inverted hexagonal structure would result in the destruction of cell membrane function. Such an interaction of positive charge-modified AuNPs with the membrane mimics provides a promising route to develop new antibacterial agents by modifying positive charges on the surface of nanoparticles.
DOI10.1021/acs.langmuir.8b01700
WOS KeywordX-RAY-DIFFRACTION ; MODEL CELL-MEMBRANES ; INVERTED HEXAGONAL PHASE ; GRAM-NEGATIVE BACTERIA ; SILVER NANOPARTICLES ; LIPID-BILAYERS ; HII PHASE ; CURVATURE ; MECHANISM ; TRANSITIONS
Indexed BySCI ; EI
Language英语
WOS Research AreaPhysics
WOS SubjectPhysics, Particles & Fields
WOS IDWOS:000448752700008
EI Accession Number20184205954865
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/286707
Collection多学科研究中心
实验物理中心
加速器中心
Corresponding AuthorWu ZH(吴忠华)
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Corresponding Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Xing XQ,Xing, XQ,Zhao XY,et al. Interaction between Surface Charge-Modified Gold Nanoparticles and Phospholipid Membranes[J]. LANGMUIR,2018,34(42):12583-12589.
APA 邢雪青.,Xing, XQ.,赵晓艺.,王佳怡.,姚磊.,...&Wu, ZH.(2018).Interaction between Surface Charge-Modified Gold Nanoparticles and Phospholipid Membranes.LANGMUIR,34(42),12583-12589.
MLA 邢雪青,et al."Interaction between Surface Charge-Modified Gold Nanoparticles and Phospholipid Membranes".LANGMUIR 34.42(2018):12583-12589.
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