| Selenoprotein P as the major transporter for mercury in serum from methylmercury-poisoned rats | |
刘洋(多); Zhang W(张伟) ; Zhao JT(赵甲亭); Lin XY(林晓影); Cui LW(崔丽巍); Gao YX(高愈希); Li B(李柏); Li YF(李玉锋); Liu, Yang; Zhang, Wei; Zhao, Jiating; Lin, Xiaoying; Liu, Jiamei; Cui, Liwei; Gao, Yuxi; Zhang, Tian-Lan; Li, Bai; Li, Yu-Feng
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| 2018 | |
| Source Publication | JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
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| ISSN | 0946-672X |
| Volume | 50Pages:589-595 |
| Subtype | Article; Proceedings Paper |
| Abstract | Selenium (Se) has been found to promote weight gain, decrease hepatic damage, but redistribute mercury (Hg) in brains and livers in methylmercury (MeHg)-poisoned rats. The aims of the present work were to examine the effects of Se on the levels of Hg in serum and the role of serum selenoproteins in binding with Hg in MeHg-poisoned rats. The concentration of Se, Hg and MeHg were studied using ICP-MS and CVAFS. The Hg- and Se binding selenoproteins were separated and quantified using affinity chromatography with post-column isotope dilution analysis using both enriched Se-78 and Hg-199. It was found that Se treatment reduced Hg levels in serum in MeHg-poisoned rats. Among the three separated selenoproteins, the amounts of SelP-bound Hg and Se increased to 73% and 93.6%, from 64.4% and 89.3% of the total Hg and Se, respectively after Se treatment, suggesting that SelP acts as a major transporter for Hg and pool for Se in serum. Over 90% of the total Hg was MeHg in serum, and the molar ratios of MeHg to Se as 1:4 and 1:9 in the formed MeHg-Se-SelP complex in the control and the Se treatment group, respectively. The elevated Se level binding with SelP facilitated the Hg extraction from tissues and organs, as well as its redistribution in brains and livers through blood circulation in the MeHg-poisoned rats. Together, our findings provide direct evidence that serum SelP is the major Hg transporter in MeHg-poisoned rats. |
| Conference Title | Joint 16th International Symposium on Trace Elements in Man and Animals (TEMA) / 12th Conference of the International-Society-for-Trace-Element-Research-in-Humans (ISTERH) / 13th Conference of the Nordic-Trace-Element-Society (NTES) |
| Conference Place | St Petersburg, RUSSIA |
| Keyword | Methylmercury Selenium Selenoprotein P Isotope dilution |
| DOI | 10.1016/j.jtemb.2018.04.013 |
| WOS Keyword | SELENIUM |
| Indexed By | SCI ; CPCI ; MEDLINE |
| Language | 英语 |
| WOS Research Area | Astronomy & Astrophysics |
| WOS Subject | Astronomy & Astrophysics |
| WOS ID | WOS:000448633900079 |
| MedlineID | MEDLINE:29704998 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/286698 |
| Collection | 多学科研究中心 实验物理中心 加速器中心 |
| Corresponding Author | Li YF(李玉锋) |
| Affiliation | 中国科学院高能物理研究所 |
| First Author Affilication | Institute of High Energy |
| Corresponding Author Affilication | Institute of High Energy |
| Recommended Citation GB/T 7714 | Liu Y,Zhang W,Zhao JT,et al. Selenoprotein P as the major transporter for mercury in serum from methylmercury-poisoned rats[J]. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,2018,50:589-595. |
| APA | 刘洋.,张伟.,赵甲亭.,林晓影.,崔丽巍.,...&Li, Yu-Feng.(2018).Selenoprotein P as the major transporter for mercury in serum from methylmercury-poisoned rats.JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,50,589-595. |
| MLA | 刘洋,et al."Selenoprotein P as the major transporter for mercury in serum from methylmercury-poisoned rats".JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY 50(2018):589-595. |
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