IHEP OpenIR  > 多学科研究中心
Gd@C-82(OH)(22) harnesses inflammatory regeneration for osteogenesis of mesenchymal stem cells through JNK/STAT3 signaling pathway
Lin, Jiao; Cai, Rong; Sun BY(孙宝云); Dong JQ(董金泉); Sun, Baoyun; Dong, Jinquan; Zhao, Yuliang; Miao, Qing; Chen, Chunying
2018
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
EISSN2050-7518
Volume6Issue:36Pages:5802-5811
SubtypeArticle
AbstractTissue injuries are inevitably accompanied with immune responses. Understanding the effects of biomaterials on immunology regulation is critical for biomaterial development and tissue regeneration. Inflammatory cytokines secreted from macrophages promote the migration of mesenchymal stem cells (MSCs) to the damaged tissue sites and their subsequent participation in tissue repair. However, the effects of inflammatory cytokines caused by tissue injury on MSC behaviors urgently need to be revealed. Understanding and subsequently manipulating the interactions between immune cells and stem cells will provide us with new therapeutic strategies for tissue regeneration. Nanoparticles having immunomodulatory properties can modulate MSCs' functions in the inflammatory microenvironment. In this study, an immunomodulatory nanoparticle Gd@C-82(OH)(22) was used to manipulate MSC differentiation in inflammatory microenvironment. The results suggested that macrophage-derived inflammation induces osteogenic differentiation of MSCs by activating the JNK/STAT3 pathway. Gd@C-82(OH)(22) modulates inflammation-induced differentiation of MSCs in a dose-dependent manner through the JNK/STAT3 pathway. Low concentration of Gd@C-82(OH)(22) facilitates osteogenesis and high concentration suppresses osteogenesis of hMSCs in the inflammatory microenvironment. This study suggests that Gd@C-82(OH)(22) can act as a promising immunomodulator to differentiate stem cells and improve stem cell-based therapeutic efficiency for biomedical regeneration in inflammatory microenvironments.
DOI10.1039/c8tb01097h
WOS KeywordOSTEOBLAST DIFFERENTIATION ; TISSUE REGENERATION ; IMMUNE-RESPONSE ; BONE REPAIR ; MACROPHAGES ; NANOPARTICLES ; FRACTURE ; RUNX2 ; MICROENVIRONMENT ; METASTASIS
Indexed BySCI ; EI
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000448413200015
EI Accession Number20183905861844
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/286620
Collection多学科研究中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Lin, Jiao,Cai, Rong,Sun BY,et al. Gd@C-82(OH)(22) harnesses inflammatory regeneration for osteogenesis of mesenchymal stem cells through JNK/STAT3 signaling pathway[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(36):5802-5811.
APA Lin, Jiao.,Cai, Rong.,孙宝云.,董金泉.,Sun, Baoyun.,...&Chen, Chunying.(2018).Gd@C-82(OH)(22) harnesses inflammatory regeneration for osteogenesis of mesenchymal stem cells through JNK/STAT3 signaling pathway.JOURNAL OF MATERIALS CHEMISTRY B,6(36),5802-5811.
MLA Lin, Jiao,et al."Gd@C-82(OH)(22) harnesses inflammatory regeneration for osteogenesis of mesenchymal stem cells through JNK/STAT3 signaling pathway".JOURNAL OF MATERIALS CHEMISTRY B 6.36(2018):5802-5811.
Files in This Item:
File Name/Size DocType Version Access License
20181153.pdf(3325KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lin, Jiao]'s Articles
[Cai, Rong]'s Articles
[孙宝云]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lin, Jiao]'s Articles
[Cai, Rong]'s Articles
[孙宝云]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lin, Jiao]'s Articles
[Cai, Rong]'s Articles
[孙宝云]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.