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Harnessing Tumor Microenvironment for Nanoparticle‐Mediated Radiotherapy
朱双; 谷战军; 赵宇亮; Shuang Zhu; Zhanjun Gu; Yuliang Zhao
AbstractRecent years have witnessed the dramatic improvement of nanoparticle‐mediated radiotherapy in preclinical or even clinical cancer research. Among the extensive developments, tumor‐targeted strategies are receiving more and more attention as they become able increase their therapeutic effects as well as reduce the side effects to healthy tissues. The tumor microenvironment (TME) with its critical function in tumor development and distinctive abnormal characteristics, is also widely studied as a target/response for tumor‐specific nano‐radiotherapy. The fast advances of TME‐assisted nano‐radiotherapy have offered numerous novel strategies and approaches for efficiently destroying cancer. This review summarizes the recent advances and development of TME‐enabled nanoparticle‐mediated radiotherapy. Firstly, a brief description of the typical TME characteristics including vasculature, hypoxia, mild acidity, redox reactions, extracellular matrix, and various cellular components is given. Next, the representative examples of TME‐enabled nanoparticle‐mediated radiotherapy are categorized and discussed in two parts: TME components–targeted nano‐radiotherapy and TME characteristics‐responsive nano‐radiotherapy. Lastly, some obstacles and challenges associated with this field are also proposed at the end of this review.
Keywordnanoparticles radiotherapy targeted therapy tumor microenvironments
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Document Type期刊论文
Corresponding Author谷战军
First Author AffilicationInstitute of High Energy
Corresponding Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
朱双,谷战军,赵宇亮,等. Harnessing Tumor Microenvironment for Nanoparticle‐Mediated Radiotherapy[J]. ADVANCED THERAPEUTICS,2018,1(5):1800050.
APA 朱双,谷战军,赵宇亮,Shuang Zhu,Zhanjun Gu,&Yuliang Zhao.(2018).Harnessing Tumor Microenvironment for Nanoparticle‐Mediated Radiotherapy.ADVANCED THERAPEUTICS,1(5),1800050.
MLA 朱双,et al."Harnessing Tumor Microenvironment for Nanoparticle‐Mediated Radiotherapy".ADVANCED THERAPEUTICS 1.5(2018):1800050.
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