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Frequency Shift Raman-Based Sensing of Serum MicroRNAs for Early Diagnosis and Discrimination of Primary Liver Cancers
Zhu WF(朱文凤); Cheng LX(程林秀); Li M(李敏); Zhuang HJ(庄洪军); Xie D(谢丹); Zhao YL(赵宇亮); Zhu, WF; Cheng, LX; Li, M; Zuo, D; Zhang, N; Zhuang, HJ; Xie, D; Zeng, QD; Hutchison, JA; Zhao, YL
2018
Source PublicationANALYTICAL CHEMISTRY
ISSN0003-2700
EISSN1520-6882
Volume90Issue:17Pages:10144-10151
SubtypeArticle
AbstractFrequency shift surface-enhanced Raman scattering (SERS) achieves multiplex microRNA sensing for early serological diagnosis of, and discrimination between, primary liver cancers in a patient cohort for whom only biopsy is effective clinically. Raman reporters microprinted on plasmonic substrates shift their vibrational frequencies upon biomarker binding with a dynamic range allowing direct, multiplex assay of serum microRNAs and the current best protein biomarker, alpha-fetoprotein. Benchmarking against current gold-standard polymerase chain reaction and chemiluminescence methods validates the assay. The work further establishes the frequency shift approach, sensing shifts in an intense SERS band, as a viable alternative to conventional SERS sensing which involves the more difficult task of resolving a peak above noise at ultralow analyte concentrations.
DOI10.1021/acs.analchem.8b01798
WOS KeywordHEPATOCELLULAR-CARCINOMA ; SPECTROSCOPY ; HYBRIDIZATION ; INFECTION ; DISEASE ; TRENDS ; DNA
Indexed BySCI ; EI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000444060600012
EI Accession Number20182805543233
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/286290
Collection多学科研究中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Zhu WF,Cheng LX,Li M,et al. Frequency Shift Raman-Based Sensing of Serum MicroRNAs for Early Diagnosis and Discrimination of Primary Liver Cancers[J]. ANALYTICAL CHEMISTRY,2018,90(17):10144-10151.
APA 朱文凤.,程林秀.,李敏.,庄洪军.,谢丹.,...&Zhao, YL.(2018).Frequency Shift Raman-Based Sensing of Serum MicroRNAs for Early Diagnosis and Discrimination of Primary Liver Cancers.ANALYTICAL CHEMISTRY,90(17),10144-10151.
MLA 朱文凤,et al."Frequency Shift Raman-Based Sensing of Serum MicroRNAs for Early Diagnosis and Discrimination of Primary Liver Cancers".ANALYTICAL CHEMISTRY 90.17(2018):10144-10151.
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