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Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy
Li, ZL; Hu, SS; Liu J(刘晶); Chen CY(陈春英); Liu, J; Hu, Y; Chen, L; Jiang, TT; Sun, L; Sun, Y; Besenbacher, F; Chen, CY; Yu, M
2018
Source PublicationPARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
ISSN0934-0866
EISSN1521-4117
Volume35Issue:8Pages:1800127
SubtypeArticle
AbstractBiocompatible single-component theranostic nanoagents instinctly affording multiple imaging modalities with satisfying therapeutic functions are highly desirable for anticancer treatments. Although cobalt-based phosphides are well-recognized as competent electrocatalysts, their potentials for biomedical applications remain unexplored. In this work, cobalt phosphide nanoparticles (CoP NPs) are developed to be a powerful theranostic agent for multimodal imaging and anticancer photothermal therapy. The uniform CoP NPs in a size of approximate to 21 nm are synthesized via a facile thermal decomposition method, followed by surface modification. The resultant CoP NPs exhibit excellent compatibility and stability in water as well as various physiological solutions. Supported by the good biocompatibility, strong near-infrared absorption, and high photothermal conversion property, significant photothermal effect of the NPs is demonstrated, realizing efficient hyperthermia ablation on cancer cells. Importantly, the CoP NPs have shown considerable capabilities on high-contrast in vitro and in vivo triple-modal imaging, including infrared thermal (IRT), photoacoustic (PA), and T-2-weighted magnetic resonance (MR) imaging. This work has unraveled the promising potentials of CoP-based nanoagent for precise diagnosis and efficient therapy.
Keywordcobalt phosphide nanoparticles magnetic resonance imaging photoacoustic imaging photothermal therapy theranostic nanoagent
DOI10.1002/ppsc.201800127
WOS KeywordPRUSSIAN BLUE NANOPARTICLES ; LAYER MOS2 NANOSHEETS ; NEAR-INFRARED LIGHT ; DRUG-DELIVERY ; CANCER-THERAPY ; NANOCRYSTALS ; ABLATION ; GRAPHENE ; NANODOTS ; PLATFORM
Indexed BySCI ; EI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000441893400010
EI Accession Number20183405725447
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/286230
Collection多学科研究中心
实验物理中心
粒子天体物理中心
理论物理室
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Li, ZL,Hu, SS,Liu J,et al. Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy[J]. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,2018,35(8):1800127.
APA Li, ZL.,Hu, SS.,刘晶.,陈春英.,Liu, J.,...&Yu, M.(2018).Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy.PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION,35(8),1800127.
MLA Li, ZL,et al."Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy".PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION 35.8(2018):1800127.
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