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Three-dimensional angiography fused with CT/MRI for multimodal imaging of nanoparticles based on Ba4Yb3F17:Lu3+,Gd3+
Ma SH(马思汉); Zhang JX(张佳欣); Xia SB(夏士博); Yin WY(尹文艳); Qin YX(秦艳霞); Lei RH(雷润宏); Kong JL(孔江龙); Mei LQ(梅林强); Li J(李娟); Xing GM(邢更妹); Ma, SH; Zhang, JX; Xia, SB; Yin, WY; Qin, YX; Lei, RH; Kong, JL; Mei, LQ; Li, J; Xin, GM; Li, GP
2018
Source PublicationNANOSCALE
ISSN2040-3364
EISSN2040-3372
Volume10Issue:28Pages:13402-13409
SubtypeArticle
AbstractDesigning nanosized multi-modality contrast agents for high-resolution imaging is challenging since most agents are only useful for single-mode imaging. In this work, we successfully synthesized biocompatible polyethylene glycol (PEG-) and l-glutamine (GLN-) modified Ba4Yb3F17:Lu3+,Gd3+ nanoparticles (LNPs@PEG@GLN) that can be employed as a multi-modality contrast agent. Fluorescence dye-modified LNPs@PEG@GLN nanoparticles can be used for computed tomography (CT), magnetic resonance imaging (MRI), and fluorescence imaging (FI). They display high X-ray absorption, outstanding T-2-weighted imaging capability, and good fluorescence uptake. Furthermore, LNPs@PEG@GLN enhances contrast efficiencies for different imaging modalities in vivo. Interestingly, LNPs@PEG@GLN is a promising agent for CT angiography. These nanoparticles could be a promising contrast agent for multi-modality imaging and diagnosing vascular diseases.
DOI10.1039/c8nr03054e
WOS KeywordRAY COMPUTED-TOMOGRAPHY ; UP-CONVERSION NANOPARTICLES ; BINARY CONTRAST AGENT ; IN-VIVO ; CT ; NANOPHOSPHORS ; NANOCRYSTALS ; LUMINESCENCE ; MRI ; ANGIOGENESIS
Indexed BySCI ; EI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000439319000013
EI Accession Number20183005597166
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/286142
Collection多学科研究中心
加速器中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Ma SH,Zhang JX,Xia SB,et al. Three-dimensional angiography fused with CT/MRI for multimodal imaging of nanoparticles based on Ba4Yb3F17:Lu3+,Gd3+[J]. NANOSCALE,2018,10(28):13402-13409.
APA 马思汉.,张佳欣.,夏士博.,尹文艳.,秦艳霞.,...&Li, GP.(2018).Three-dimensional angiography fused with CT/MRI for multimodal imaging of nanoparticles based on Ba4Yb3F17:Lu3+,Gd3+.NANOSCALE,10(28),13402-13409.
MLA 马思汉,et al."Three-dimensional angiography fused with CT/MRI for multimodal imaging of nanoparticles based on Ba4Yb3F17:Lu3+,Gd3+".NANOSCALE 10.28(2018):13402-13409.
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