| Acute Oral Administration of Single-Walled Carbon Nanotubes Increases Intestinal Permeability and Inflammatory Responses: Association with the Changes in Gut Microbiota in Mice | |
Chen HQ(陈汉清) ; Wang B(汪冰); Zheng LN(郑令娜); Ou YH(欧阳宏); Wang HL(王海龙); Zhou XY(周晓艳); Zhang D(张丹); Chai ZF(柴之芳); Zhao YL(赵宇亮); Feng WY(丰伟悦); Chen, HQ; Zhao, RF; Wang, B; Zheng, LN; Ouyang, H; Wang, HL; Zhou, XY; Zhang, D; Chai, ZF; Zhao, YL; Feng, WY
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| 2018 | |
| Source Publication | ADVANCED HEALTHCARE MATERIALS
 |
| ISSN | 2192-2640 |
| EISSN | 2192-2659 |
| Volume | 7Issue:13Pages:1701313 |
| Subtype | Article |
| Abstract | With the increasing production and widespread potential applications of single-walled carbon nanotubes (SWCNTs), the possible impacts of oral administration of SWCNTs on gastrointestinal tract at currently occupational exposure limits and potential biomedical applications should be concerned. To address the concerns, mice are orally administrated of SWCNTs at doses of 0.05, 0.5, and 2.5 mg kg(-1) body weight per day for 7 d. The investigation shows that SWCNT treatment had promoted intestinal injuries at the acute dose of 2.5 mg kg(-1) per day, including increase of histological lesion scores, intestinal permeability, and proinflammatory cytokine (IL-1 beta, IL-6, and TNF-) secretion. Analysis of gut microbiota composition using 16S rRNA gene sequencing approach reveals that acute oral administration of SWCNTs induces significant shifts of the predominant microbe phyla from Firmicutes to Bacteroidetes and increases abundance of proinflammatory bacteria Alitipes_uncultured_bacterium and Lachnospiraceae bacterium A4. These notable findings suggest that SWCNT-induced intestinal injury is linked to SWCNT interaction with intestinal tract and gut bacteria and the consequent triggering of metabolic inflammation responses. Furthermore, the study has shown that oral administration of carbon nanomaterials, including SWCNTs, multiwalled CNTs, and graphene oxide, can lead to different inflammatory responses and specific alteration in gut microbiota in mice. |
| Keyword | acute oral administration gut inflammatory response gut microbiota intestinal permeability single-walled carbon nanotubes |
| DOI | 10.1002/adhm.201701313 |
| WOS Keyword | NANOPARTICLES ; BACTERIA ; COLITIS ; METABOLISM ; OBESITY |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Engineering ; Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials |
| WOS ID | WOS:000438193900001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/286110 |
| Collection | 多学科研究中心 |
| Corresponding Author | Feng WY(丰伟悦) |
| Affiliation | 中国科学院高能物理研究所 |
| First Author Affilication | Institute of High Energy |
| Corresponding Author Affilication | Institute of High Energy |
| Recommended Citation GB/T 7714 | Chen HQ,Wang B,Zheng LN,et al. Acute Oral Administration of Single-Walled Carbon Nanotubes Increases Intestinal Permeability and Inflammatory Responses: Association with the Changes in Gut Microbiota in Mice[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(13):1701313. |
| APA | 陈汉清.,汪冰.,郑令娜.,欧阳宏.,王海龙.,...&Feng, WY.(2018).Acute Oral Administration of Single-Walled Carbon Nanotubes Increases Intestinal Permeability and Inflammatory Responses: Association with the Changes in Gut Microbiota in Mice.ADVANCED HEALTHCARE MATERIALS,7(13),1701313. |
| MLA | 陈汉清,et al."Acute Oral Administration of Single-Walled Carbon Nanotubes Increases Intestinal Permeability and Inflammatory Responses: Association with the Changes in Gut Microbiota in Mice".ADVANCED HEALTHCARE MATERIALS 7.13(2018):1701313. |
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