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Walking the line: The fate of nanomaterials at biological barriers
Meng, H; Leong, W; Leong, KW; Chen, CY; Zhao, YL; Chen CY(陈春英); Zhao YL(赵宇亮)
2018
Source PublicationBIOMATERIALS
ISSN0142-9612
EISSN1878-5905
Volume174Pages:41-53
SubtypeReview
AbstractBiological systems have developed an efficient multi-tiered defense system to block foreign substances such as engineered nanomaterials (NMs) from causing damage. In a pathological scenario, the disease itself may also pose additional barriers due to the imbalance between abnormal cells and their surrounding microenvironment, and NMs could behave similarly or differently to classic foreign substances, depending on their unique characteristics. Thus, understanding the mechanisms that govern the fate of NMs against these biological barriers, including the strategies that can be used to shift their fate between access and blockage, become key information for NMs design. In this manuscript, we first describe the biological barriers that NMs may encounter, and further discuss how these biological barrier interactions could shift the fate of NMs between toxicity and therapeutic potential. A list of effects that may influence NMs access at nano/bio interface are presented and discussed, followed by personal insights on the important nano/bio topics that require additional research for a better understanding of NM/biological barrier interactions. (C) 2018 Elsevier Ltd. All rights reserved.
KeywordBiological barriers Nano/bio interface Nanomaterials Nanosafety Nanomedicine
DOI10.1016/j.biomaterials.2018.04.056
WOS KeywordBLOOD-BRAIN-BARRIER ; PREDICTIVE TOXICOLOGICAL APPROACH ; MESOPOROUS SILICA NANOPARTICLES ; HUMAN PANCREATIC-CANCER ; PROTEIN CORONA ; DRUG-DELIVERY ; QUANTUM DOTS ; MACROMOLECULAR THERAPEUTICS ; ENHANCED PERMEABILITY ; SILVER NANOPARTICLES
Indexed BySCI ; EI
Language英语
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000436223500004
EI Accession Number20182105236072
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/286058
Collection多学科研究中心
Corresponding AuthorZhao YL(赵宇亮)
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Corresponding Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Meng, H,Leong, W,Leong, KW,et al. Walking the line: The fate of nanomaterials at biological barriers[J]. BIOMATERIALS,2018,174:41-53.
APA Meng, H.,Leong, W.,Leong, KW.,Chen, CY.,Zhao, YL.,...&赵宇亮.(2018).Walking the line: The fate of nanomaterials at biological barriers.BIOMATERIALS,174,41-53.
MLA Meng, H,et al."Walking the line: The fate of nanomaterials at biological barriers".BIOMATERIALS 174(2018):41-53.
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