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Small size fullerenol nanoparticles suppress lung metastasis of breast cancer cell by disrupting actin dynamics
Qin YX(秦艳霞); Chen K(陈奎); Gu WH(古伟宏); Dong XH(董兴华); Lei RH(雷润宏); Chang YN(常亚男); Bai X(白雪); Xia SB(夏士博); Ceng L(曾立); Zhang JX(张佳欣); Ma SH(马思汉); Li J(李娟); Xing GM(邢更妹); Qin, YX; Chen, K; Gu, WH; Dong, XH; Lei, RH; Chang, YN; Bai, X; Xia, SB; Zeng, L; Zhang, JX; Ma, SH; Li, J; Li, S; Xing, GM
2018
Source PublicationJOURNAL OF NANOBIOTECHNOLOGY
ISSN1477-3155
Volume16Pages:54
SubtypeArticle
AbstractBackground: Tumor metastasis is the primary cause of mortality in cancer patients. Migratory breast cancer cells in lymphatic and blood vessels seek new sites and form metastatic colonies in the lung and bone, and then these cancer cells often wreak considerable havoc. With advances in nanotechnology, nanomaterials and nanotechnologies are widely applied in tumor therapy. In this paper, small size fullerenol nanoparticles, which are separated by isoelectric focusing electrophoresis (IFE) for discrepancy of isoelectric point (pl), are used in the study of tumor metastasis. Results: In this study, the commendable inhibition of tumor metastasis was uncovered by intravenous injection of purified fullerenol fraction with special surface charge and functional groups, which was separated by IFE for discrepancy of pl. By investigating the actin dynamics in several cancer cell lines, we found these small size fullerenol nanoparticles disturbed actin dynamics. Young's modulus detection and cell migration assays revealed that fullerenol lowered stiffness and restrained migration of breast cancer cells. Filopodia, the main supporting structures of actin bundles, are important for cell motility and adhesion. Scanning electron microscopy showed that fullerenol reduced the number and length of filopodia. Simultaneously, the inhibition of integrin to form clusters on filopodias, which was likely induced by reorganizing of actin cytoskeleton, impacted cancer cell adhesion and motility. Conclusions: With intravenous injection of these fullerenol nanoparticles, tumor metastasis is well inhibited in vivo. The underlying mechanism most likely to be attributed to the effect of fullerenol nanoparticles on disturbing actin dynamics. With the disordered actin fiber, cell function is varied, including decreased cell stiffness, reduced filopodia formation, and inactivated integrin.
KeywordFullerenol nanoparticles Metastasis Actin dynamics Young's modulus Filopodia
DOI10.1186/s12951-018-0380-z
WOS KeywordMECHANICAL-PROPERTIES ; MATRIX DEGRADATION ; TUMOR-METASTASIS ; IN-VITRO ; CYTOSKELETON ; MIGRATION ; INVASION ; INTEGRIN ; ORGANIZATION ; REORGANIZATION
Indexed BySCI ; EI ; MEDLINE
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Science & Technology - Other Topics
WOS SubjectBiotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
WOS IDWOS:000436142400001
EI Accession Number20182605375813
MedlineIDMEDLINE:29935539
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/286041
Collection多学科研究中心
加速器中心
Corresponding AuthorXing GM(邢更妹)
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Corresponding Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Qin YX,Chen K,Gu WH,et al. Small size fullerenol nanoparticles suppress lung metastasis of breast cancer cell by disrupting actin dynamics[J]. JOURNAL OF NANOBIOTECHNOLOGY,2018,16:54.
APA 秦艳霞.,陈奎.,古伟宏.,董兴华.,雷润宏.,...&Xing, GM.(2018).Small size fullerenol nanoparticles suppress lung metastasis of breast cancer cell by disrupting actin dynamics.JOURNAL OF NANOBIOTECHNOLOGY,16,54.
MLA 秦艳霞,et al."Small size fullerenol nanoparticles suppress lung metastasis of breast cancer cell by disrupting actin dynamics".JOURNAL OF NANOBIOTECHNOLOGY 16(2018):54.
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