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Effects of Fullerenol Nanoparticles on Rat Oocyte Meiosis Resumption
Lei RH(雷润宏); Bai X(白雪); Chang YN(常亚男); Li J(李娟); Qin YX(秦艳霞); Chen K(陈奎); Gu WH(古伟宏); Xia SB(夏士博); Zhang JX(张佳欣); Xing GM(邢更妹); Lei, RH; Bai, X; Chang, YN; Li, J; Qin, YX; Chen, K; Gu, WH; Xia, SB; Zhang, JX; Wang, ZB; Xing, GM
2018
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1422-0067
Volume19Issue:3Pages:699
SubtypeArticle
AbstractThe excellent biocompatibility and biological effects of fullerenol and its derivatives make their biomedical application promising. The potential effects of fullerenol in mammals have been extensively studied, but little is known about its effects on female reproduction. Using canonical oocyte-granulosa cell complexes (OGCs) in vitro maturation culture model, we investigated the effect of fullerenol on the first oocyte meiotic resumption. In the surrounding granulosa cells, fullerenol nanoparticles occluded the extracellular domain of the epidermal growth factor receptor (EGFR) to reduce EGFR-ligand binding and subsequent extracellular signal-regulated kinase 1 and 2 (ERK1/2) activation, which involved the regulation of connexin 43 (CX43) expression and internalization. Downregulation of CX43 expression and the retraction of transzonal projections (TZPs) interrupted the gap junction channel and TZPs based mass transportation. This effect decreased cyclic adenosine monophosphate (cAMP) levels in the oocyte and thereby accelerated rat oocyte meiosis resumption. Moreover, perinuclear distribution of CX43 and EGFR was observed in granulosa cells, which could further exacerbate the effects. Fullerenol nanoparticles interfered with the strict process of oocyte meiosis resumption, which likely reduced the oocyte quality.
Keywordfullerenol oocyte meiosis resumption gap junction granulosa cells EGFR/ERK1/2
DOI10.3390/ijms19030699
WOS KeywordTITANIUM-DIOXIDE NANOPARTICLES ; SILVER ALLOY NANOPARTICLES ; GAP-JUNCTION ENDOCYTOSIS ; REPRODUCTIVE TOXICITY ; MAMMALIAN OOCYTE ; DEVELOPMENTAL COMPETENCE ; MEIOTIC MATURATION ; GRANULOSA-CELLS ; GRAPHENE OXIDE ; GROWTH-FACTORS
Indexed BySCI ; MEDLINE
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000428309800056
MedlineIDMEDLINE:29494500
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285992
Collection多学科研究中心
加速器中心
Corresponding AuthorXing GM(邢更妹)
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Corresponding Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Lei RH,Bai X,Chang YN,et al. Effects of Fullerenol Nanoparticles on Rat Oocyte Meiosis Resumption[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2018,19(3):699.
APA 雷润宏.,白雪.,常亚男.,李娟.,秦艳霞.,...&Xing, GM.(2018).Effects of Fullerenol Nanoparticles on Rat Oocyte Meiosis Resumption.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,19(3),699.
MLA 雷润宏,et al."Effects of Fullerenol Nanoparticles on Rat Oocyte Meiosis Resumption".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 19.3(2018):699.
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