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Investigation of the sustained-release mechanism of hydroxypropyl methyl cellulose skeleton type Acipimox tablets
Liu, WY; Huo, Q; Wang, Y; Yu, N; Shi, RJ; Shi RJ(史戎坚)
2018
Source PublicationOPEN CHEMISTRY
ISSN2391-5420
Volume16Issue:1Pages:333-339
SubtypeArticle
AbstractIn this study, we investigate the production of hypolipidemic agents in the form of Acipimox sustained-release tablets, using a wet pelleting process. The purpose of this research is to reduce the total intake time for patients and to lower the initial dose in such that the adverse reactions could be reduced. This study adopts the single-factor method and orthogonal experiments by using hydroxypropyl methyl cellulose (HPMC K15M) as the main sustained-release prescription composition. The final prescription is Acipimox 20%, HPMC K15M 26.67%, sodium carboxymethyl cellulose 30%, polyethylene glycol (PEG 6000) 1%, ethyl cellulose 16.6%, lactose 4.67% and magnesium stearate 1%. The dissolution of tablets reached 85.88% in 8 h. The difference in the weight, hardness and friability of the tables met the requirements in the Chinese Pharmacopoeia; to test the stability, a temperature and illumination accelerated test method was used, the results indicate that the Acipimox sustained-release tablets should be sealed and stored in a dark, cool area. A preliminary study on the tablets' releasing mechanism showed that their release curve fitted the Higuchi model (the formula is M-t/M-infinity = 31.137 t(1/)(2)-3.605 (R-2 = 0.9903)). The Acipimox tablets' release principle is dominated by the diffusion mechanism.
KeywordAcipimox sustained-release tablet sodium carboxymethylcellulose hydroxypropyl methyl cellulose
DOI10.1515/chem-2018-0036
WOS KeywordHEALTHY-VOLUNTEERS ; HYPERTRIGLYCERIDEMIA ; HYPERLIPIDEMIA ; POPULATION ; SINGLE
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000431899300005
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285899
Collection核技术应用研究中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Liu, WY,Huo, Q,Wang, Y,et al. Investigation of the sustained-release mechanism of hydroxypropyl methyl cellulose skeleton type Acipimox tablets[J]. OPEN CHEMISTRY,2018,16(1):333-339.
APA Liu, WY,Huo, Q,Wang, Y,Yu, N,Shi, RJ,&史戎坚.(2018).Investigation of the sustained-release mechanism of hydroxypropyl methyl cellulose skeleton type Acipimox tablets.OPEN CHEMISTRY,16(1),333-339.
MLA Liu, WY,et al."Investigation of the sustained-release mechanism of hydroxypropyl methyl cellulose skeleton type Acipimox tablets".OPEN CHEMISTRY 16.1(2018):333-339.
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