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Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure
Li J(李娟); Yang SM(杨生梅); Lei RH(雷润宏); Gu WH(古伟宏); Qin YX(秦艳霞); Ma SH(马思汉); Chen K(陈奎); Chang YN(常亚男); Bai X(白雪); Xia SB(夏士博); Xing GM(邢更妹); Li, J; Yang, SM; Lei, RH; Gu, WH; Qin, YX; Ma, SH; Chen, K; Chang, YA; Bai, X; Xia, SB; Wu, CM; Xing, GM
2018
Source PublicationNANOSCALE
ISSN2040-3364
EISSN2040-3372
Volume10Issue:16Pages:7736-7745
SubtypeArticle
AbstractThe widespread application of TiO2 nanoparticles (NPs) as additives in foods such as gum, candy and puddings has dramatically increased the human ingestion and accumulation of these nanomaterials. Although the toxicity of TiO2 NPs has been extensively studied, their impact on gut microbiota in vivo still needs further research. In this study, TiO2 NPs with two main crystalline phases anatase and rutile were orally administrated to mice for 28 days. The dynamic influences of anatase and rutile on gut microbiota structures were investigated at doses equivalent to those consumed by people who love to eat candies. The results showed that titanium accumulated in the spleen, lung, and kidney but had no significant effects on organ histology. Gavage of rutile NPs but not anatase NPs resulted in longer intestinal villi and irregular arrangement of villus epithelial cells. Treatment with TiO2 NPs did not decrease gut microbiota diversity but shifted their structures in a time-dependent manner. Rutile NPs had a more pronounced influence on the gut microbiota than anatase NPs. The most influenced phylum was Proteobacteria, which was significantly increased by rutile but not by anatase. At the genus level, Prevotella was significantly decreased by both the TiO2 NPs, Rhodococcus was enriched by rutile NPs, and Bacteroides was increased by anatase NPs. Overall, these results suggested that chronic overconsumption of TiO2 NP-containing foods is likely to deteriorate the gastrointestinal tract and change the structures of microbiota. The crystalline phases may play an important role in mediating the intestinal impact of TiO2 NPs.
DOI10.1039/c8nr00386f
WOS KeywordTITANIUM-DIOXIDE NANOPARTICLES ; UNDERSTANDING BIOPHYSICOCHEMICAL INTERACTIONS ; FOOD-GRADE ; TOXICITY ; LIVER ; TRANSFORMATION ; GENOTOXICITY ; GENERATION ; PARTICLES ; PRODUCTS
Indexed BySCI ; EI ; MEDLINE
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000431030000048
EI Accession Number20181805121679
MedlineIDMEDLINE:29658026
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285881
Collection多学科研究中心
Corresponding AuthorXing GM(邢更妹)
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Corresponding Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Li J,Yang SM,Lei RH,et al. Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure[J]. NANOSCALE,2018,10(16):7736-7745.
APA 李娟.,杨生梅.,雷润宏.,古伟宏.,秦艳霞.,...&Xing, GM.(2018).Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure.NANOSCALE,10(16),7736-7745.
MLA 李娟,et al."Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure".NANOSCALE 10.16(2018):7736-7745.
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