IHEP OpenIR  > 多学科研究中心
Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure
Li J(李娟); Yang SM(杨生梅); Lei RH(雷润宏); Gu WH(古伟宏); Qin YX(秦艳霞); Ma SH(马思汉); Chen K(陈奎); Chang YN(常亚男); Bai X(白雪); Xia SB(夏士博); Xing GM(邢更妹); Li, J; Yang, SM; Lei, RH; Gu, WH; Qin, YX; Ma, SH; Chen, K; Chang, YA; Bai, X; Xia, SB; Wu, CM; Xing, GM
Source PublicationNANOSCALE
AbstractThe widespread application of TiO2 nanoparticles (NPs) as additives in foods such as gum, candy and puddings has dramatically increased the human ingestion and accumulation of these nanomaterials. Although the toxicity of TiO2 NPs has been extensively studied, their impact on gut microbiota in vivo still needs further research. In this study, TiO2 NPs with two main crystalline phases anatase and rutile were orally administrated to mice for 28 days. The dynamic influences of anatase and rutile on gut microbiota structures were investigated at doses equivalent to those consumed by people who love to eat candies. The results showed that titanium accumulated in the spleen, lung, and kidney but had no significant effects on organ histology. Gavage of rutile NPs but not anatase NPs resulted in longer intestinal villi and irregular arrangement of villus epithelial cells. Treatment with TiO2 NPs did not decrease gut microbiota diversity but shifted their structures in a time-dependent manner. Rutile NPs had a more pronounced influence on the gut microbiota than anatase NPs. The most influenced phylum was Proteobacteria, which was significantly increased by rutile but not by anatase. At the genus level, Prevotella was significantly decreased by both the TiO2 NPs, Rhodococcus was enriched by rutile NPs, and Bacteroides was increased by anatase NPs. Overall, these results suggested that chronic overconsumption of TiO2 NP-containing foods is likely to deteriorate the gastrointestinal tract and change the structures of microbiota. The crystalline phases may play an important role in mediating the intestinal impact of TiO2 NPs.
Indexed BySCI ; EI ; MEDLINE
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000431030000048
EI Accession Number20181805121679
Citation statistics
Document Type期刊论文
Corresponding AuthorXing GM(邢更妹)
First Author AffilicationInstitute of High Energy
Corresponding Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Li J,Yang SM,Lei RH,et al. Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure[J]. NANOSCALE,2018,10(16):7736-7745.
APA 李娟.,杨生梅.,雷润宏.,古伟宏.,秦艳霞.,...&Xing, GM.(2018).Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure.NANOSCALE,10(16),7736-7745.
MLA 李娟,et al."Oral administration of rutile and anatase TiO2 nanoparticles shifts mouse gut microbiota structure".NANOSCALE 10.16(2018):7736-7745.
Files in This Item:
File Name/Size DocType Version Access License
20180397.pdf(3982KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[李娟]'s Articles
[杨生梅]'s Articles
[雷润宏]'s Articles
Baidu academic
Similar articles in Baidu academic
[李娟]'s Articles
[杨生梅]'s Articles
[雷润宏]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[李娟]'s Articles
[杨生梅]'s Articles
[雷润宏]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.