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Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa
Xia SB(夏士博); Li J(李娟); Zu M(祖勉); Li JX(李金霞); Liu JK(刘金珂); Chang YN(常亚男); Chen K(陈奎); Gu WH(古伟宏); Zhao LN(赵丽娜); Xing GM(邢更妹); Xia, SB; Li, J; Zu, M; Li, JX; Liu, JK; Bai, X; Chang, YA; Chen, K; Gu, WH; Zeng, L; Zhao, LN; Xing, GY; Xing, GM
2018
Source PublicationNANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE
ISSN1549-9634
EISSN1549-9642
Volume14Issue:3Pages:929-939
SubtypeArticle
AbstractThrombus is one of main causes of death in the world and also a vital trouble of biomaterials application in vivo. Recently, effect of fullerenol nanomaterials on anticoagulation was found in our research through extension of bleeding times in treated Sprague-Dawley rats via intravenous injection. Inhibiting of fullerenols on thrombosis was ascertained further by thromboembolism model. Effects of fullerenols on intrinsic and extrinsic pathway were distinct in prolonging activated partial thromboplastin time and prothrombin time, which supported that fullerenols induced defects in both pathways. Inhibited activities of activated coagulation factor X (FXa) and thrombin were verified by experiments in vitro and AutoDock Vina. The results suggest that fullerenols depending on small size and certainly surface property occupied the active domain of FXa and thrombin to block their activity; further, thrombosis was inhibited. This putative mechanism offers an insight into how fullerenol NPs were utilized further in biomedical applications. (c) 2018 Elsevier Inc. All rights reserved.
KeywordFullerenols Anticoagulation Thrombin FXa Ca2+ Inhibition of thrombosis
DOI10.1016/j.nano.2017.12.013
WOS KeywordPLATELET-AGGREGATION ; ANTITHROMBOTIC ACTIVITIES ; PROCOAGULANT ACTIVITY ; STEM-CELLS ; IN-VITRO ; FIBRINOGEN ; ANTICOAGULANT ; BINDING ; PERMEABILITY ; SUPPRESSION
Indexed BySCI ; EI ; MEDLINE
Language英语
WOS Research AreaScience & Technology - Other Topics ; Research & Experimental Medicine
WOS SubjectNanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS IDWOS:000429528900027
EI Accession Number20181004855337
MedlineIDMEDLINE:29309909
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285806
Collection多学科研究中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Xia SB,Li J,Zu M,et al. Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa[J]. NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE,2018,14(3):929-939.
APA 夏士博.,李娟.,祖勉.,李金霞.,刘金珂.,...&Xing, GM.(2018).Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa.NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE,14(3),929-939.
MLA 夏士博,et al."Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and FXa".NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE 14.3(2018):929-939.
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