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Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing
Guo BY(郭秉元); Guo, BY; Zhou K(周柯); Liu QS(刘全胜); 刘蕾(多); Sheng, YY; Zhou, K; Liu, QS; Liu, L; Wu, HC
2018
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
EISSN1521-3773
Volume57Issue:14Pages:3602-3606
SubtypeArticle
AbstractA new nanopore sensing strategy based on triplex molecular beacon was developed for the detection of specific DNA or multivalent proteins. The sensor is composed of a triplex-forming molecular beacon and a stem-forming DNA component that is modified with a host-guest complex. Upon target DNA hybridizing with the molecular beacon loop or multivalent proteins binding to the recognition elements on the stem, the DNA probe is released and produces highly characteristic current signals when translocated through -hemolysin. The frequency of current signatures can be used to quantify the concentrations of the target molecules. This sensing approach provides a simple, quick, and modular tool for the detection of specific macromolecules with high sensitivity and excellent selectivity. It may find useful applications in point-of-care diagnostics with a portable nanopore kit in the future.
Keywordantibodies biomarkers molecular beacon nanopore sensors quantitative determination
DOI10.1002/anie.201711690
WOS KeywordALPHA-HEMOLYSIN NANOPORE ; CANCER-PATIENTS ; NUCLEIC-ACIDS ; SOLID-STATE ; SINGLE ; PROTEIN ; BIOMARKERS ; ANTIBODY ; DISCRIMINATION ; NANOSTRUCTURES
Indexed BySCI ; EI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000428350100008
EI Accession Number20180904850387
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285778
Collection多学科研究中心
核技术应用研究中心
Corresponding Author刘蕾(多)
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Corresponding Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Guo BY,Guo, BY,Zhou K,et al. Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(14):3602-3606.
APA 郭秉元.,Guo, BY.,周柯.,刘全胜.,刘蕾.,...&Wu, HC.(2018).Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(14),3602-3606.
MLA 郭秉元,et al."Analyte-Triggered DNA-Probe Release from a Triplex Molecular Beacon for Nanopore Sensing".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.14(2018):3602-3606.
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