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Inhibition of Lysozyme Fibrillation by Gold Nanorods and Nanoparticles
Liang, HL; Wang B(汪冰); Wang HL(王海龙); Yu M(俞淼); Zheng LN(郑令娜); Wang M(王萌); Feng WY(丰伟悦); Wang, B; Wang, HL; Yu, M; Zheng, LN; Wang, M; Zhang, AP; Feng, WY
2018
Source PublicationJOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN1533-4880
EISSN1533-4899
Volume18Issue:5Pages:3087-3094
SubtypeArticle
AbstractAmyloid fibrillation has been implicated in many neurodegenerations, dialysis-related amyloidosis, type II diabetes and more than 30 other amyloid- related diseases. Nanomaterials as potential inhibitors of amyloid fibrillation have attracted increasing interests. In the present study, the effects of gold nanorods (AuNRs) and nanoparticles (AuNPs) on amyloid fibrillation were investigated using hen egg white lysozyme (HEWL) as a model system. Our results indicated that AuNRs and AuNPs, especially AuNRs, present significant inhibitory effects on HEWL amyloid fibril formation during all the kinetic processes, from nucleation to elongation and equilibration stages. The stronger adsorption capacity of HEWL on AuNRs surface is the key mechanism of inhibition of HEWL amyloid fibrillation. Furthermore, AuNRs lead to more stable alpha-helix conformation and hydrophobic microenvironment of aromatic side groups in HEWL molecules, which facilitate the system to form small amorphous aggregates rather than oligomer, profibril or mature fibril.
KeywordGold Nanorods and Nanoparticles Lysozyme Fibrillation Inhibition Effects
DOI10.1166/jnn.2018.14662
WOS KeywordAMYLOID-BETA OLIGOMERIZATION ; PROTEIN FIBRILLATION ; POLYMERIC NANOPARTICLES ; SIZE ; AGGREGATION ; NUCLEATION ; PATHWAYS
Indexed BySCI ; EI
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000426040800006
EI Accession Number20180204629792
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285685
Collection多学科研究中心
Corresponding AuthorFeng WY(丰伟悦)
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Corresponding Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Liang, HL,Wang B,Wang HL,et al. Inhibition of Lysozyme Fibrillation by Gold Nanorods and Nanoparticles[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2018,18(5):3087-3094.
APA Liang, HL.,汪冰.,王海龙.,俞淼.,郑令娜.,...&Feng, WY.(2018).Inhibition of Lysozyme Fibrillation by Gold Nanorods and Nanoparticles.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,18(5),3087-3094.
MLA Liang, HL,et al."Inhibition of Lysozyme Fibrillation by Gold Nanorods and Nanoparticles".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 18.5(2018):3087-3094.
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