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Impact of Titanium Dioxide and Fullerenol Nanoparticles on Caco-2 Gut Epithelial Cells
Yang SM(杨生梅); Xiong FX(熊凤霞); Chen K(陈奎); Chang YN(常亚男); Bai X(白雪); Yin WY(尹文艳); Gu WH(古伟宏); Wang QY(王前源); Li J(李娟); Yang, SM; Xiong, FX; Chen, K; Chang, YA; Bai, X; Yin, WY; Gu, WH; Wang, QY; Li, J; Chen, GG
AbstractThe application of nano-products in the food industry increases the risk of people exposed to nanoparticles. Titanium dioxide nanoparticles (T-NPs) are typically and widely used in food field, while fullerenol nanoparticles (F-NPs) have great promise to be used as food additives. Therefore, it is necessary and important to understand the safety of T-NPs and F-NPs in foods. In the present study, Caco-2 gut epithelial cell line was selected as a model to investigate the impact of T-NPs and F-NPs. The viability and proliferation of Caco-2 gut epithelial cells incubated with different concentrations of T-NPs and F-NPs were observed. The results showed that the two kinds of nanoparticles did not induce cell death even lasting for 48 h. The results of apoptosis and DNA damages in the cells indicated that both T-NPs with 50 and 100 mu g/mL caused Caco-2 gut epithelial cell apoptosis, but didn't cause significantly DNA damages. F-NPs with 200 and 500 mu g/mL concentrations also can induce cell apoptosis but no DNA damage.
KeywordCaco-2 Gut Epithelial Cells Titanium Dioxide Fullerenol Nanoparticles
WOS KeywordROS
Indexed BySCI ; EI
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000426050500016
EI Accession Number20180204625767
Citation statistics
Document Type期刊论文
Corresponding AuthorLi J(李娟)
First Author AffilicationInstitute of High Energy
Corresponding Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Yang SM,Xiong FX,Chen K,et al. Impact of Titanium Dioxide and Fullerenol Nanoparticles on Caco-2 Gut Epithelial Cells[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2018,18(4):2387-2393.
APA 杨生梅.,熊凤霞.,陈奎.,常亚男.,白雪.,...&Chen, GG.(2018).Impact of Titanium Dioxide and Fullerenol Nanoparticles on Caco-2 Gut Epithelial Cells.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,18(4),2387-2393.
MLA 杨生梅,et al."Impact of Titanium Dioxide and Fullerenol Nanoparticles on Caco-2 Gut Epithelial Cells".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 18.4(2018):2387-2393.
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