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Intelligent MoS2 Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery To Overcome Cancer Chemotherapy Resistance Guided by PET Imaging
Dong XH(董兴华); Yin WY(尹文艳); Zhang X(张潇); Zhu S(朱双); He X(何潇); Yu J(余杰); Xie JN(谢佳妮); Guo Z(郭兆); Yan L(晏亮); Gu ZJ(谷战军); Zhao YL(赵宇亮); Dong, XH; Yin, WY; Zhang, X; Zhu, S; He, X; Yu, J; Xie, JN; Guo, Z; Yan, L; Liu, XF; Wang, Q; Gu, ZJ; Zhao, YL
2018
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume10Issue:4Pages:4271-4284
SubtypeArticle
AbstractChemotherapy resistance remains a major hurdle for cancer therapy in clinic because of the poor cellular uptake and insufficient intracellular release of dings. Herein, an intelligent, multifunctional MoS2 nanotheranostic (MoS2-PEI-HA) ingeniously decorated with biodegradable hyaluronic acid (HA) assisted by polyethyleneimine (PEI) is reported to combat drug-resistant breast, cancer (MCF-7-ADR) after loading with the chemotherapy drug doxorubicin (DOX). HA can not only target CD44-overexpressing MCF-7-ADR but also be degraded by hyaluronidase (HAase) that is concentrated in the tumor microenvironment, thus accelerating DOX release. Furthermore, MoS2 with strong near-infrared (NIR) photothermal conversion ability can also promote the release of DOX in the acidic tumor environment at a mild 808 nm laser irradiation, achieving a superior antitumor activity based on the programmed response to HAase and NIR laser actuator. Most importantly, HA targeting combined with mild NIR laser stimuli, rather than using hyperthermia, can potently downregulate the expression of drug resistance-related Pllycoprotein (P-gp), resulting in greatly enhanced intracellular drug accumulation, thus achieving drug resistance reversal. After labeled with Cu-64 by a simple chelation strategy, MoS2 was employed for real-time positron emission tomography (PET) imaging of MCF-7-ADR tumor in vivo. This multifunctional nanoplatform paves a new avenue for PET imaging-guided spatial-temporal-controlled accurate therapy of drug-resistant cancer.
KeywordMoS2 nanosheets surface modification targeting and P-gp inhibition controlled therapy theranostics
DOI10.1021/acsami.7b17506
WOS KeywordMETAL DICHALCOGENIDE NANOSHEETS ; UP-CONVERSION NANOPARTICLES ; PRODUCT P-GLYCOPROTEIN ; ONE-POT SYNTHESIS ; IN-VIVO ; POLYMERIC MICELLES ; PHOTOTHERMAL THERAPY ; TUMOR ; DOXORUBICIN ; GENE
Indexed BySCI ; EI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000424728800125
EI Accession Number20180604753296
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285655
Collection多学科研究中心
实验物理中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Dong XH,Yin WY,Zhang X,et al. Intelligent MoS2 Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery To Overcome Cancer Chemotherapy Resistance Guided by PET Imaging[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(4):4271-4284.
APA 董兴华.,尹文艳.,张潇.,朱双.,何潇.,...&Zhao, YL.(2018).Intelligent MoS2 Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery To Overcome Cancer Chemotherapy Resistance Guided by PET Imaging.ACS APPLIED MATERIALS & INTERFACES,10(4),4271-4284.
MLA 董兴华,et al."Intelligent MoS2 Nanotheranostic for Targeted and Enzyme-/pH-/NIR-Responsive Drug Delivery To Overcome Cancer Chemotherapy Resistance Guided by PET Imaging".ACS APPLIED MATERIALS & INTERFACES 10.4(2018):4271-4284.
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