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多功能纳米材料在肿瘤放疗增敏中的应用
Alternative TitleApplication of Multifunctional Nanomaterials in Tumor Radiosensitization
龚林吉; 谢佳妮; 朱双; 谷战军; 赵宇亮; Gong, LJ; Xie, JN; Zhu, S; Gu, ZJ; Zhao, YL
2018
Source Publication物理化学学报
ISSN1000-6818
Volume34Issue:2Pages:140-167
SubtypeReview
AbstractRadiation therapy kills tumor cells via focused high energy radiation, and has become one of the most common and effective clinical treatments for malignant tumors. However, some limitations restrict its clinical efficacy, including a requirement for elevated doses of radiation, side effects due to exposure of healthy tissue, and especially radioresistance of tumor cells. With the development of nanomedicine, multifunctional nanoradiosensitizers offer a new route to improve the efficiency of radiation therapy. In this paper, we summarize the main types of nanoradiosensitizers and their applications in radiation therapy, especially those that have currently entered clinical trials. We also summarize the main approaches to nanomaterials-based radiosensitization, and discuss the factors influencing their application. Finally, the challenges and prospects of multifunctional nanoradiosensitizers are presented.
KeywordRadiation therapy Nanoradiosensitizer Radiosensitization mechanism Nanomedicine
DOI10.3866/PKU.WHXB201707174
WOS KeywordGADOLINIUM-BASED NANOPARTICLES ; IRON-OXIDE NANOPARTICLES ; CANCER RADIATION-THERAPY ; RAY COMPUTED-TOMOGRAPHY ; MESOPOROUS SILICA NANOPARTICLES ; RADIO-PHOTOTHERMAL THERAPY ; METAL-BASED NANOPARTICLES ; WALLED CARBON NANOTUBES ; NEAR-INFRARED WINDOW ; ONE-POT SYNTHESIS
Indexed BySCI
Language中文
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
WOS IDWOS:000423693100007
CSCD IDCSCD:6167828
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285579
Collection实验物理中心
多学科研究中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
龚林吉,谢佳妮,朱双,等. 多功能纳米材料在肿瘤放疗增敏中的应用[J]. 物理化学学报,2018,34(2):140-167.
APA 龚林吉.,谢佳妮.,朱双.,谷战军.,赵宇亮.,...&Zhao, YL.(2018).多功能纳米材料在肿瘤放疗增敏中的应用.物理化学学报,34(2),140-167.
MLA 龚林吉,et al."多功能纳米材料在肿瘤放疗增敏中的应用".物理化学学报 34.2(2018):140-167.
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