| Biodegradable MoOx nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window | |
Yin WY(尹文艳) ; Bo T(薄涛); Zhang X(张潇); Gao Q(高琴); Yu J(余杰); Dong XH(董兴华); Gu ZJ(谷战军); Zhao YL(赵宇亮); Yin, WY; Bao, T; Zhang, X; Gao, Q; Yu, J; Dong, XH; Yan, L; Gu, ZJ; Zhao, YL
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| 2018 | |
| Source Publication | NANOSCALE
 |
| ISSN | 2040-3364 |
| EISSN | 2040-3372 |
| Volume | 10Issue:3Pages:1517-1531 |
| Subtype | Article |
| Abstract | Near-infrared (NIR) laser induced phototherapy has been considered as a noninvasive option for cancer therapy. Herein, we report plasmonic PEGylated molybdenum oxide nanoparticles (PEG-MoOx NPs) that were synthesized by using a facile hydrothermal method. The PEG-MoOx NPs exhibit broad absorption at the NIR biological window and remarkable photothermal conversion ability in the first (808 nm) and the second (1064 nm) windows. Moreover, the biocompatible PEG-MoOx NPs exhibit effective cellular uptake and could be eliminated gradually from the liver and spleen in mice. Studies on the therapeutic effects of these NPs under 808 and 1064 nm exposures with mild hyperthermia are conducted. According to the result, exposure to 1064 nm irradiation can not only effectively convert light into heat but also sensitize the formation of reactive oxygen species (ROS), which exert dramatic cancer cell death and suppression in vivo due to the synergic effect of photothermal therapy (PTT) and photodynamic therapy (PDT). In marked contrast, 808 nm irradiation can only execute limited PTT to cancer cells, showing a relatively low inhibition rate in vitro and in vivo. This biodegradable MoOx nanoplatform with synergetic PTT and PDT functionalities upon 1064 nm irradiation provided emerging opportunities for the phototherapy of cancer in nanomedicine. |
| DOI | 10.1039/c7nr07927c |
| WOS Keyword | SURFACE-PLASMON RESONANCES ; IN-VIVO ; GOLD NANORODS ; SEMICONDUCTOR NANOCRYSTALS ; MILD HYPERTHERMIA ; TUNGSTEN-OXIDE ; SINGLET OXYGEN ; 1064 NM ; LIGHT ; NANOMATERIALS |
| Indexed By | SCI ; EI ; MEDLINE |
| Language | 英语 |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| WOS ID | WOS:000423259000069 |
| EI Accession Number | 20180404679482 |
| MedlineID | MEDLINE:29303196 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/285571 |
| Collection | 多学科研究中心 实验物理中心 |
| Corresponding Author | Gu ZJ(谷战军) |
| Affiliation | 中国科学院高能物理研究所 |
| First Author Affilication | Institute of High Energy |
| Corresponding Author Affilication | Institute of High Energy |
| Recommended Citation GB/T 7714 | Yin WY,Bo T,Zhang X,et al. Biodegradable MoOx nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window[J]. NANOSCALE,2018,10(3):1517-1531. |
| APA | 尹文艳.,薄涛.,张潇.,高琴.,余杰.,...&Zhao, YL.(2018).Biodegradable MoOx nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window.NANOSCALE,10(3),1517-1531. |
| MLA | 尹文艳,et al."Biodegradable MoOx nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window".NANOSCALE 10.3(2018):1517-1531. |
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