IHEP OpenIR  > 多学科研究中心
Peroxidase-like activity of MoS2 nanoflakes with different modifications and their application for H2O2 and glucose detection
Yu J(余杰); Ma DQ(马东清); Mei LQ(梅林强); Gao Q(高琴); Yin WY(尹文艳); Zhang X(张潇); Yan L(晏亮); Gu ZJ(谷战军); Zhao YL(赵宇亮); Yu, J; Ma, DQ; Mei, LQ; Gao, Q; Yin, WY; Zhang, X; Yan, L; Gu, ZJ; Ma, XY; Zhao, YL
2018
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
EISSN2050-7518
Volume6Issue:3Pages:487-498
SubtypeArticle
AbstractMoS2 nanoflakes (MoS2 NFs) with a diameter of B390 nm were obtained by a facile one-pot hydrothermal method and the NFs exhibited intrinsic peroxidase-like activity. After being modified by commonly used biocompatible surfactants including polyethyleneimine (PEI), polyacrylic acid (PAA), polyvinylpyrrolidone (PVP), and cysteine (Cys), the peroxidase-like catalytic activities of MoS2 NFs were investigated by using 3,30,5,50-tetramethylbenzidine (TMB) and 2,20-azino-bis(3-ethylbenzothiazoline-6sulfonic acid) diammonium salt (ABTS) as chromogenic substrates. Compared to the polymer modified MoS2 NFs, Cys functionalized MoS2 NFs exhibited a high catalytic activity toward H2O2 in the presence of TMB or ABTS. Zeta potential and Michaelis-Menten analyses implied that the electrostatic force induced affinity or repulsion between the MoS2 NFs and substrates, as well as surface modifications of the MoS2 NFs played a key role in the catalytic reactions. Notably, a new peroxidase-like catalytic reaction mechanism was proposed based on the formation of a transient state of Cys-MoS2 NFs containing H2O2 and ABTS, and the catalytic reaction could occur because the Cys on the surface of the MoS2 NFs served as an electron transfer bridge between H2O2 and ABTS. Based on this finding, we also established a platform for colorimetric detection of H2O2 and glucose using Cys-MoS2 NFs as a peroxidase substitution. The limit of detection (LOD) was determined to be 4.103 mmol L-1 for H2O2, and the linear range (LR) was from 0 to 0.3 mmol L-1. The LOD for glucose was 33.51 mmol L-1 and the LR was from 0.05 to 1 mmol L-1, which is suitable for biomedical diagnosis. This work provides a new insight into the catalytic mechanism of peroxidase-like MoS2 NFs, and paves the way for enzyme-like nanomaterials to be used for medical diagnosis.
DOI10.1039/c7tb02676e
WOS KeywordMOLYBDENUM-DISULFIDE ; GOLD NANOPARTICLES ; CATALYTIC-ACTIVITY ; ELECTROCHEMICAL DETECTION ; COLORIMETRIC DETECTION ; IRIDIUM NANOPARTICLES ; SYNERGISTIC CATALYST ; PHOTOTHERMAL THERAPY ; HYDROGEN-PEROXIDE ; POLYACRYLIC-ACID
Indexed BySCI ; EI
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
WOS IDWOS:000422871100014
EI Accession Number20180404679367
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285545
Collection多学科研究中心
实验物理中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Yu J,Ma DQ,Mei LQ,et al. Peroxidase-like activity of MoS2 nanoflakes with different modifications and their application for H2O2 and glucose detection[J]. JOURNAL OF MATERIALS CHEMISTRY B,2018,6(3):487-498.
APA 余杰.,马东清.,梅林强.,高琴.,尹文艳.,...&Zhao, YL.(2018).Peroxidase-like activity of MoS2 nanoflakes with different modifications and their application for H2O2 and glucose detection.JOURNAL OF MATERIALS CHEMISTRY B,6(3),487-498.
MLA 余杰,et al."Peroxidase-like activity of MoS2 nanoflakes with different modifications and their application for H2O2 and glucose detection".JOURNAL OF MATERIALS CHEMISTRY B 6.3(2018):487-498.
Files in This Item:
File Name/Size DocType Version Access License
20180058.pdf(3751KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[余杰]'s Articles
[马东清]'s Articles
[梅林强]'s Articles
Baidu academic
Similar articles in Baidu academic
[余杰]'s Articles
[马东清]'s Articles
[梅林强]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[余杰]'s Articles
[马东清]'s Articles
[梅林强]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.