| The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo | |
Li J(李娟) ; Lei RH(雷润宏); Xiong FX(熊凤霞); Yang SM(杨生梅); Chang YN(常亚男); Chen K(陈奎); Gu WH(古伟宏); Xing GM(邢更妹); Li, J; Lei, RH; Li, X; Xiong, FX; Zhang, QY; Zhou, Y; Yang, SM; Chang, YA; Chen, K; Gu, WH; Wu, CM; Xing, GM
| |
| 2018 | |
| Source Publication | PARTICLE AND FIBRE TOXICOLOGY
 |
| ISSN | 1743-8977 |
| Volume | 15Pages:5 |
| Subtype | Article |
| Abstract | Background: Nanoparticles (NPs) administered orally will meet the gut microbiota, but their impacts on microbiota homeostasis and the consequent physiological relevance remain largely unknown. Here, we describe the modulatory effects and the consequent pharmacological outputs of two orally administered fullerenols NPs (Fol1 C-60(OH)(7)(O)(8) and Fol113 C-60(OH)(11)(O)(6)) on gut microbiota. Results: Administration of Fol1 and Fol113 NPs for 4 weeks largely shifted the overall structure of gut microbiota in mice. The bacteria belonging to putative short-chain fatty acids (SCFAs)-producing genera were markedly increased by both NPs, especially Fol1. Dynamic analysis showed that major SCFAs-producers and key butyrate-producing gene were significantly enriched after treatment for 7-28 days. The fecal contents of SCFAs were consequently increased, which was accompanied by significant decreases of triglycerides and total cholesterol levels in the blood and liver, with Fol1 superior to Fol113. Under cultivation in vitro, fullerenols NPs can be degraded by gut flora and exhibited a similar capacity of inulin to promote SCFA-producing genera. The differential effects of Fol1 and Fol113 NPs on the microbiome may be attributable to their subtly varied surface structures. Conclusions: The two fullerenol NPs remarkably modulate the gut microbiota and selectively enrich SCFA-producing bacteria, which may be an important reason for their anti-hyperlipidemic effect in mice. |
| Keyword | Fullerenols Gut microbiota Short-chain fatty acid (SCFA) Blood lipids Butyrate-producing bacteria |
| DOI | 10.1186/s12989-018-0241-9 |
| WOS Keyword | CHAIN FATTY-ACIDS ; CARBON NANOTUBES ; METABOLITES ; BACTERIA ; INSIGHTS ; THERAPY ; HEALTH ; MICE ; C-60 |
| Indexed By | SCI ; MEDLINE |
| Language | 英语 |
| WOS Research Area | Toxicology |
| WOS Subject | Toxicology |
| WOS ID | WOS:000422875000001 |
| MedlineID | MEDLINE:29343276 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/285544 |
| Collection | 多学科研究中心 |
| Corresponding Author | Xing GM(邢更妹) |
| Affiliation | 中国科学院高能物理研究所 |
| First Author Affilication | Institute of High Energy |
| Corresponding Author Affilication | Institute of High Energy |
| Recommended Citation GB/T 7714 | Li J,Lei RH,Xiong FX,et al. The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo[J]. PARTICLE AND FIBRE TOXICOLOGY,2018,15:5. |
| APA | 李娟.,雷润宏.,熊凤霞.,杨生梅.,常亚男.,...&Xing, GM.(2018).The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo.PARTICLE AND FIBRE TOXICOLOGY,15,5. |
| MLA | 李娟,et al."The antihyperlipidemic effects of fullerenol nanoparticles via adjusting the gut microbiota in vivo".PARTICLE AND FIBRE TOXICOLOGY 15(2018):5. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment