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Diffusion characteristics of the fornix in patients with Alzheimer's disease
Tang, SX; Feng, QL; Wang, GH; Duan, SF; Shan, BC; Dai, JP; Duan SF(段绍峰); Dan BC(单保慈)
2017
Source PublicationPSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
EISSN1872-7506
Volume265Pages:72-76
SubtypeArticle
AbstractWhite matter degradation is a major part of the pathogenesis of Alzheimer's disease (AD). The fornix is the predominant outflow tract from the hippocampus, and alterations to its microstructure in patients with AD are still being explored. Diffusion tensor imaging (DTI) is an in vivo neuroimaging technique that can provide unique information about alterations in tissue microstructure, which can indicate underlying neurobiological process at the microstructural level. In this prospective study, DTI was used to assess and analyze the microstructural features of the fornix in subjects with AD (n = 17), mild cognitive impairment (MCI; n = 12) and healthy controls (n = 17). DTI was performed using Explore DTI software and the FSL package. Within the fornix, patients with AD showed decreased fractional anisotropy values and length of fiber tracts of the fornix relative to healthy controls, but higher mean diffusivity values. MCI subjects showed a trend towards elevated mean diffusivity values in the fornix. The data suggest that DTI provides supporting information on the microstructural alteration of the fornix in patients with AD, and that these diffusion characteristics of the fornix may be helpful for the clinical diagnosis of AD.
KeywordFornix Alzheimer's Disease Fractional anisotropy Mean diffusion
DOI10.1016/j.pscychresns.2016.09.012
WOS KeywordMILD COGNITIVE IMPAIRMENT ; WHITE-MATTER ; EPISODIC MEMORY ; MRI ; CONNECTIVITY ; TRACTOGRAPHY ; PROGRESSION ; DISRUPTION ; INTEGRITY ; PATHWAYS
Indexed BySCI ; PUBMED ; SCOPUS
Language英语
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Neuroimaging ; Psychiatry
WOS IDWOS:000405053200009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285387
Collection多学科研究中心
核技术应用研究中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Tang, SX,Feng, QL,Wang, GH,et al. Diffusion characteristics of the fornix in patients with Alzheimer's disease[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2017,265:72-76.
APA Tang, SX.,Feng, QL.,Wang, GH.,Duan, SF.,Shan, BC.,...&单保慈.(2017).Diffusion characteristics of the fornix in patients with Alzheimer's disease.PSYCHIATRY RESEARCH-NEUROIMAGING,265,72-76.
MLA Tang, SX,et al."Diffusion characteristics of the fornix in patients with Alzheimer's disease".PSYCHIATRY RESEARCH-NEUROIMAGING 265(2017):72-76.
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