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| Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study | |
Lu, YJ; Cai, XW; Zhang, GF; Huang, Y; Tang, CZ; Shan, BC; Cui, SY; Chen, JQ; Qu, SS; Zhong, Z; Lai, XS; Steiner, GZ; Dan BC(单保慈)
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| 2017 | |
| Source Publication | NEURAL REGENERATION RESEARCH中国神经再生研究
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| ISSN | 1673-5374 |
| EISSN | 1876-7958 |
| Volume | 12Issue:7Pages:1159-1165 |
| Subtype | Article |
| Abstract | The acute effect of acupuncture on Alzheimer's disease, i.e., on brain activation during treatment, has been reported. However, the effect of long-term acupuncture on brain activation in Alzheimer's disease is unclear. Therefore, in this study, we performed long-term needling at Zusanli (ST36) or a sham point (1.5 mm lateral to ST36) in a rat Alzheimer's disease model, for 30 minutes, once per day, for 30 days. The rats underwent 1 F-fluorodeoxyglucose positron emission tomography scanning. Positron emission tomography images were processed with SPM2. The brain areas activated after needling at ST36 included the left hippocampus, the left orbital cortex, the left infralimbic cortex, the left olfactory cortex, the left cerebellum and the left pons. In the sham-point group, the activated regions were similar to those in the ST36 group. However, the ST36 group showed greater activation in the cerebellum and pons than the sham-point group. These findings suggest that long-term acupuncture treatment has targeted regulatory effects on multiple brain regions in rats with Alzheimer's disease. |
| Keyword | nerve regeneration neurodegeneration acupuncture Zusanli (ST36) Alzheimer's disease long-term treatment positron emission tomography rat mechanism targeting effect compensation multi-target regulation neural regeneration |
| DOI | 10.4103/1673-5374.211197 |
| WOS Keyword | METABOLISM |
| Indexed By | SCI ; PUBMED ; SCOPUS ; CSCD |
| Language | 英语 |
| WOS Research Area | Cell Biology ; Neurosciences & Neurology |
| WOS Subject | Cell Biology ; Neurosciences |
| WOS ID | WOS:000407199500026 |
| CSCD ID | CSCD:6045748 |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/285249 |
| Collection | 核技术应用研究中心 |
| Affiliation | 中国科学院高能物理研究所 |
| First Author Affilication | Institute of High Energy |
| Recommended Citation GB/T 7714 | Lu, YJ,Cai, XW,Zhang, GF,et al. Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study[J]. NEURAL REGENERATION RESEARCH中国神经再生研究,2017,12(7):1159-1165. |
| APA | Lu, YJ.,Cai, XW.,Zhang, GF.,Huang, Y.,Tang, CZ.,...&单保慈.(2017).Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study.NEURAL REGENERATION RESEARCH中国神经再生研究,12(7),1159-1165. |
| MLA | Lu, YJ,et al."Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study".NEURAL REGENERATION RESEARCH中国神经再生研究 12.7(2017):1159-1165. |
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