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Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study
Lu, YJ; Cai, XW; Zhang, GF; Huang, Y; Tang, CZ; Shan, BC; Cui, SY; Chen, JQ; Qu, SS; Zhong, Z; Lai, XS; Steiner, GZ; Dan BC(单保慈)
2017
Source PublicationNEURAL REGENERATION RESEARCH中国神经再生研究
ISSN1673-5374
EISSN1876-7958
Volume12Issue:7Pages:1159-1165
SubtypeArticle
AbstractThe acute effect of acupuncture on Alzheimer's disease, i.e., on brain activation during treatment, has been reported. However, the effect of long-term acupuncture on brain activation in Alzheimer's disease is unclear. Therefore, in this study, we performed long-term needling at Zusanli (ST36) or a sham point (1.5 mm lateral to ST36) in a rat Alzheimer's disease model, for 30 minutes, once per day, for 30 days. The rats underwent 1 F-fluorodeoxyglucose positron emission tomography scanning. Positron emission tomography images were processed with SPM2. The brain areas activated after needling at ST36 included the left hippocampus, the left orbital cortex, the left infralimbic cortex, the left olfactory cortex, the left cerebellum and the left pons. In the sham-point group, the activated regions were similar to those in the ST36 group. However, the ST36 group showed greater activation in the cerebellum and pons than the sham-point group. These findings suggest that long-term acupuncture treatment has targeted regulatory effects on multiple brain regions in rats with Alzheimer's disease.
Keywordnerve regeneration neurodegeneration acupuncture Zusanli (ST36) Alzheimer's disease long-term treatment positron emission tomography rat mechanism targeting effect compensation multi-target regulation neural regeneration
DOI10.4103/1673-5374.211197
WOS KeywordMETABOLISM
Indexed BySCI ; PUBMED ; SCOPUS ; CSCD
Language英语
WOS Research AreaCell Biology ; Neurosciences & Neurology
WOS SubjectCell Biology ; Neurosciences
WOS IDWOS:000407199500026
CSCD IDCSCD:6045748
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285249
Collection核技术应用研究中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Lu, YJ,Cai, XW,Zhang, GF,et al. Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study[J]. NEURAL REGENERATION RESEARCH中国神经再生研究,2017,12(7):1159-1165.
APA Lu, YJ.,Cai, XW.,Zhang, GF.,Huang, Y.,Tang, CZ.,...&单保慈.(2017).Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study.NEURAL REGENERATION RESEARCH中国神经再生研究,12(7),1159-1165.
MLA Lu, YJ,et al."Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer's disease: a positron emission tomography study".NEURAL REGENERATION RESEARCH中国神经再生研究 12.7(2017):1159-1165.
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