| Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells | |
Lu HR(卢会茹); Chen J(陈俊) ; Huang H(黄辉); Zhou MX(周梦雪); Chai ZF(柴之芳); Hu Y(胡毅); Lu, HR; Chen, J; Huang, H; Zhou, MX; Zhu, Q; Yao, SQ; Chai, ZF; Hu, Y
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| 2017 | |
| Source Publication | BIOMETALS
 |
| ISSN | 0966-0844 |
| EISSN | 1572-8773 |
| Volume | 30Issue:4Pages:599-607 |
| Subtype | Article |
| Abstract | Both monoamine oxidase B (MAO-B) and iron accumulation are associated with neurologic diseases including Parkinson's disease. However, the association of iron with MAO-B activity was poorly understood. Here we took advantage of highly sensitive and specific fluorescence probes to examine the change in MAO-B activity in human dopaminergic neuroblastoma (SH-SY5Y) cells upon iron exposure. Both ferric and ferrous ions could significantly enhance the activity of MAO-B, instead of MAO-A, in SH-SY5Y cells. In addition, iron-induced increase in MAO-B probe fluorescence could be prevented by pargyline and other newly developed MAO-B inhibitors, suggesting that it was MAO-B activity-dependent. These findings may suggest MAO-B is an important sensor in iron-stressed neuronal cells. |
| Keyword | Iron MAO-B Fluorescence probe |
| DOI | 10.1007/s10534-017-0030-1 |
| WOS Keyword | PARKINSONS-DISEASE ; NEURODEGENERATIVE DISEASES ; INHIBITOR DRUGS ; BRAIN ; PROBE ; NEUROTOXICITY ; METAANALYSIS ; ANTIOXIDANT ; DERIVATIVES ; PREVENTION |
| Indexed By | SCI ; PUBMED ; MEDLINE ; SCOPUS |
| Language | 英语 |
| WOS Research Area | Biochemistry & Molecular Biology |
| WOS Subject | Biochemistry & Molecular Biology |
| WOS ID | WOS:000405780200011 |
| MedlineID | MEDLINE:28685208 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/285237 |
| Collection | 多学科研究中心 实验物理中心 |
| Affiliation | 中国科学院高能物理研究所 |
| First Author Affilication | Institute of High Energy |
| Recommended Citation GB/T 7714 | Lu HR,Chen J,Huang H,et al. Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells[J]. BIOMETALS,2017,30(4):599-607. |
| APA | 卢会茹.,陈俊.,黄辉.,周梦雪.,柴之芳.,...&Hu, Y.(2017).Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells.BIOMETALS,30(4),599-607. |
| MLA | 卢会茹,et al."Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells".BIOMETALS 30.4(2017):599-607. |
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