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Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells
Lu HR(卢会茹); Chen J(陈俊); Huang H(黄辉); Zhou MX(周梦雪); Chai ZF(柴之芳); Hu Y(胡毅); Lu, HR; Chen, J; Huang, H; Zhou, MX; Zhu, Q; Yao, SQ; Chai, ZF; Hu, Y
2017
Source PublicationBIOMETALS
ISSN0966-0844
EISSN1572-8773
Volume30Issue:4Pages:599-607
SubtypeArticle
AbstractBoth monoamine oxidase B (MAO-B) and iron accumulation are associated with neurologic diseases including Parkinson's disease. However, the association of iron with MAO-B activity was poorly understood. Here we took advantage of highly sensitive and specific fluorescence probes to examine the change in MAO-B activity in human dopaminergic neuroblastoma (SH-SY5Y) cells upon iron exposure. Both ferric and ferrous ions could significantly enhance the activity of MAO-B, instead of MAO-A, in SH-SY5Y cells. In addition, iron-induced increase in MAO-B probe fluorescence could be prevented by pargyline and other newly developed MAO-B inhibitors, suggesting that it was MAO-B activity-dependent. These findings may suggest MAO-B is an important sensor in iron-stressed neuronal cells.
KeywordIron MAO-B Fluorescence probe
DOI10.1007/s10534-017-0030-1
WOS KeywordPARKINSONS-DISEASE ; NEURODEGENERATIVE DISEASES ; INHIBITOR DRUGS ; BRAIN ; PROBE ; NEUROTOXICITY ; METAANALYSIS ; ANTIOXIDANT ; DERIVATIVES ; PREVENTION
Indexed BySCI ; PUBMED ; MEDLINE ; SCOPUS
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000405780200011
MedlineIDMEDLINE:28685208
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Document Type期刊论文
Identifierhttp://ir.ihep.ac.cn/handle/311005/285237
Collection多学科研究中心
实验物理中心
Affiliation中国科学院高能物理研究所
First Author AffilicationInstitute of High Energy
Recommended Citation
GB/T 7714
Lu HR,Chen J,Huang H,et al. Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells[J]. BIOMETALS,2017,30(4):599-607.
APA 卢会茹.,陈俊.,黄辉.,周梦雪.,柴之芳.,...&Hu, Y.(2017).Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells.BIOMETALS,30(4),599-607.
MLA 卢会茹,et al."Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells".BIOMETALS 30.4(2017):599-607.
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