| Diffusion characteristics of the fornix in patients with Alzheimer's disease | |
Tang, SX; Feng, QL; Wang, GH ; Duan, SF; Shan, BC; Dai, JP; Duan SF(段绍峰); Dan BC(单保慈)
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| 2017 | |
| Source Publication | PSYCHIATRY RESEARCH-NEUROIMAGING
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| ISSN | 0925-4927 |
| EISSN | 1872-7506 |
| Volume | 265Pages:72-76 |
| Subtype | Article |
| Abstract | White matter degradation is a major part of the pathogenesis of Alzheimer's disease (AD). The fornix is the predominant outflow tract from the hippocampus, and alterations to its microstructure in patients with AD are still being explored. Diffusion tensor imaging (DTI) is an in vivo neuroimaging technique that can provide unique information about alterations in tissue microstructure, which can indicate underlying neurobiological process at the microstructural level. In this prospective study, DTI was used to assess and analyze the microstructural features of the fornix in subjects with AD (n = 17), mild cognitive impairment (MCI; n = 12) and healthy controls (n = 17). DTI was performed using Explore DTI software and the FSL package. Within the fornix, patients with AD showed decreased fractional anisotropy values and length of fiber tracts of the fornix relative to healthy controls, but higher mean diffusivity values. MCI subjects showed a trend towards elevated mean diffusivity values in the fornix. The data suggest that DTI provides supporting information on the microstructural alteration of the fornix in patients with AD, and that these diffusion characteristics of the fornix may be helpful for the clinical diagnosis of AD. |
| Keyword | Fornix Alzheimer's Disease Fractional anisotropy Mean diffusion |
| DOI | 10.1016/j.pscychresns.2016.09.012 |
| WOS Keyword | MILD COGNITIVE IMPAIRMENT ; WHITE-MATTER ; EPISODIC MEMORY ; MRI ; CONNECTIVITY ; TRACTOGRAPHY ; PROGRESSION ; DISRUPTION ; INTEGRITY ; PATHWAYS |
| Indexed By | SCI ; PUBMED ; SCOPUS |
| Language | 英语 |
| WOS Research Area | Neurosciences & Neurology ; Psychiatry |
| WOS Subject | Clinical Neurology ; Neuroimaging ; Psychiatry |
| WOS ID | WOS:000405053200009 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihep.ac.cn/handle/311005/285231 |
| Collection | 多学科研究中心 核技术应用研究中心 |
| Affiliation | 中国科学院高能物理研究所 |
| First Author Affilication | Institute of High Energy |
| Recommended Citation GB/T 7714 | Tang, SX,Feng, QL,Wang, GH,et al. Diffusion characteristics of the fornix in patients with Alzheimer's disease[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2017,265:72-76. |
| APA | Tang, SX.,Feng, QL.,Wang, GH.,Duan, SF.,Shan, BC.,...&单保慈.(2017).Diffusion characteristics of the fornix in patients with Alzheimer's disease.PSYCHIATRY RESEARCH-NEUROIMAGING,265,72-76. |
| MLA | Tang, SX,et al."Diffusion characteristics of the fornix in patients with Alzheimer's disease".PSYCHIATRY RESEARCH-NEUROIMAGING 265(2017):72-76. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 20170703.pdf（291KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text | |
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